Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more.
Biochem Pharmacol
"the multiple first exons represent only a first layer of complexity orchestrated probably by tissue-specific transcription factors. Modulation of alternative first exon activity by epigenetic methylation of their promoters represents a second layer of complexity at least partially controlled by perinatal programming. The alternative promoter usage also appears to affect the 3' splicing generating the different GR coding variants, GRalpha, GRbeta, and GR-P."
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