Just had coffee celebrating my first year of #ubuntu. Cool beans. @ubuntuka @WebDevOnLinux @planetubuntu @jonobacon

It started as an experiment.

Over the past twelve months Ubuntu it stopped being an experiment and became my modus operandi.

Was there a singular epiphany for me?  I don't think so.  It felt more like watching the sun rise a few times, with each installation.  On my notebook, I've done fresh installs of Karmic and Lucid; and the Meerkat upgrade.  My daughter has UNE on her netbook.

Many thanks to the Ubuntu community.  

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DNA as historical GPS.

Genes predict village of origin in rural Europe

O'Dushlaine et al. Eur J Hum Genet 2010

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The heritability of general cognitive ability increases linearly from childhood to young adulthood

Haworth et al. Mol Psy 2010

A study of 11,000 twin pairs from four countries.

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Fewer sticks for diabetics? Microbead glucose monitoring.

Implantable Microbeads for Continuous Glucose Monitoring

http://stm.sciencemag.org/content/2/54/54ec164.short?etoc

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Reversal of Depressed Behaviors in Mice by p11 Gene Therapy

Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

Alexander et al. (STM, 2010) state: "These results suggest that p11 loss in rodent and human nucleus accumbens may contribute to the pathophysiology of depression. Normalization of p11 expression within this brain region with AAV-mediated gene therapy may be of therapeutic value. "

http://stm.sciencemag.org/content/2/54/54ra76.short?etoc

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Nature Medicine: Negative regulator of MAP kinase involved in depression. MKP-1.

http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2219.html

MAP kinase phosphatase 1 (MKP-1) /DUSP1.

Another study that points to this pathway, from the lab of Ron Duman.

Expression study in human post-mortem MDD brain and rat and mouse models. 

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Reboxetine Meta-Analysis Calls Into Question Veracity of All Industry-Sponsored Research

The recent meta-analysis in the British Medical Journal says Reboxetine is "ineffective and potentially harmful".  Publication bias evident.

http://www.ncbi.nlm.nih.gov/pubmed/20940209

http://www.medscape.com/viewarticle/730537

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Genetics of gene expression #GOGE -- recent paper in @PLoS

Cheung et al. PLoS Biology 2010

Polymorphic cis- and trans-regulation of human gene expression

"The majority of the regulators act in trans to the target (regulated) genes. Most of these trans-regulators were not known to play a role in gene expression regulation. The identification of these regulators enabled the characterization of polymorphic regulation of human gene expression at a resolution that was unattainable in the past."

http://www.ncbi.nlm.nih.gov/pubmed/20856902

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Epigenetic and inflammatory marker profiles associated with depression

Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample

Uddin et al. use bioinformatic analyses and find genome-wide methylation profiles differ between depressed individuals and controls.

http://www.ncbi.nlm.nih.gov/pubmed/20836906

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Allele-specific methylation in the human genome: Implications for genetic studies of complex disease

Allele-specific methylation is quantitative and heterogeneous, and increases genetic complexity of associations between loci and complex disease--

Meaburn et al. Epigenetics 2010

http://www.landesbioscience.com/journals/epigenetics/article/12960

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