Sunday, October 31, 2010
Just had coffee celebrating my first year of #ubuntu. Cool beans. @ubuntuka @WebDevOnLinux @planetubuntu @jonobacon
It started as an experiment.
Over the past twelve months Ubuntu it stopped being an experiment and became my modus operandi.
Was there a singular epiphany for me? I don't think so. It felt more like watching the sun rise a few times, with each installation. On my notebook, I've done fresh installs of Karmic and Lucid; and the Meerkat upgrade. My daughter has UNE on her netbook.
Many thanks to the Ubuntu community.
Friday, October 22, 2010
Wednesday, October 20, 2010
Implantable Microbeads for Continuous Glucose Monitoring http://stm.sciencemag.org/content/2/54/54ec164.short?etoc
Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus AccumbensAlexander et al. (STM, 2010) state: "These results suggest that p11 loss in rodent and human nucleus accumbens may contribute to the pathophysiology of depression. Normalization of p11 expression within this brain region with AAV-mediated gene therapy may be of therapeutic value. "http://stm.sciencemag.org/content/2/54/54ra76.short?etoc
Monday, October 18, 2010
MAP kinase phosphatase 1 (MKP-1) /DUSP1.
Another study that points to this pathway, from the lab of Ron Duman.
Expression study in human post-mortem MDD brain and rat and mouse models.
Friday, October 15, 2010
Monday, October 11, 2010
Cheung et al. PLoS Biology 2010
Polymorphic cis- and trans-regulation of human gene expression
"The majority of the regulators act in trans to the target (regulated) genes. Most of these trans-regulators were not known to play a role in gene expression regulation. The identification of these regulators enabled the characterization of polymorphic regulation of human gene expression at a resolution that was unattainable in the past."http://www.ncbi.nlm.nih.gov/pubmed/20856902
Monday, October 4, 2010
Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample
Uddin et al. use bioinformatic analyses and find genome-wide methylation profiles differ between depressed individuals and controls.http://www.ncbi.nlm.nih.gov/pubmed/20836906
Saturday, October 2, 2010
Allele-specific methylation in the human genome: Implications for genetic studies of complex disease
Allele-specific methylation is quantitative and heterogeneous, and increases genetic complexity of associations between loci and complex disease--
Meaburn et al. Epigenetics 2010
- Just had coffee celebrating my first year of #ubun...
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- The heritability of general cognitive ability incr...
- Fewer sticks for diabetics? Microbead glucose moni...
- Reversal of Depressed Behaviors in Mice by p11 Gen...
- Nature Medicine: Negative regulator of MAP kinase ...
- Reboxetine Meta-Analysis Calls Into Question Verac...
- Genetics of gene expression #GOGE -- recent paper ...
- Epigenetic and inflammatory marker profiles associ...
- Allele-specific methylation in the human genome: I...
- ▼ October (10)