Tuesday, August 10, 2010

Peripheral BDNF Produces Antidepressant-Like Effects in Cellular and Behavioral Models

Results from the Duman lab.  Will be interesting if replicated.

"Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM. Moreover, adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration. We also found that BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF. "

Posted via email from nocx-ville

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