Genome-Wide Divergence of DNA Methylation Marks in Cerebral and Cerebellar Cortices. Xin et al. 2010, PLoS ONE

Using methylation sensitive SNP chip methods, 

"Our large-scale genome DNA methylation profiling reveals that the

prefrontal, occipital, and temporal regions of the cerebral cortex compared to cerebellum have markedly different DNA

methylation signatures, with the cerebral cortex being hypermethylated and cerebellum being hypomethylated. Such

differences were observed in distinct genomic regions, including genes involved in CNS function. The MSNP data were

validated for a subset of these genes, by performing bisulfite cloning and sequencing and confirming that prefrontal,

occipital, and temporal cortices are significantly more methylated as compared to the cerebellum."

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