Using methylation sensitive SNP chip methods,
"Our large-scale genome DNA methylation profiling reveals that the
prefrontal, occipital, and temporal regions of the cerebral cortex compared to cerebellum have markedly different DNA
methylation signatures, with the cerebral cortex being hypermethylated and cerebellum being hypomethylated. Such
differences were observed in distinct genomic regions, including genes involved in CNS function. The MSNP data were
validated for a subset of these genes, by performing bisulfite cloning and sequencing and confirming that prefrontal,
occipital, and temporal cortices are significantly more methylated as compared to the cerebellum."