Arch Gen Psychiatry: CACNA1C allele associated with hippocampal and subgenual ACC dysfunction

This was an fMRI study in 110 healthy subjects:

"healthy carriers of the CACNA1C risk variant exhibit a pronounced reduction of bilateral hippocampal activation during episodic memory recall and diminished functional coupling between left and right hippocampal regions. Furthermore, risk allele carriers exhibit activation deficits of the subgenual anterior cingulate cortex, a region repeatedly associated with affective disorders and the mediation of adaptive stress-related responses."

This SNP was originally associated with Bipolar Disorder, by GWAS.

http://archpsyc.ama-assn.org/cgi/content/abstract/67/8/803?etoc

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