Wednesday, August 25, 2010
"commonly encountered shortcomings in fundamental aspects of experimental design mainly during biomarker discovery must be addressed in order to provide robust data. In this Perspective, we assert that successful studies generally use suitable statistical approaches for biomarker definition and confirm results in independent test sets; in addition, we describe a brief set of practical and feasible recommendations that we have developed for investigators to properly identify and qualify proteomic biomarkers, which could also be used as reporting requirements."http://stm.sciencemag.org/content/2/46/46ps42.short?etoc
Monday, August 23, 2010
Tuesday, August 17, 2010
Genome-Wide Divergence of DNA Methylation Marks in Cerebral and Cerebellar Cortices. Xin et al. 2010, PLoS ONE
Using methylation sensitive SNP chip methods,
"Our large-scale genome DNA methylation profiling reveals that the
prefrontal, occipital, and temporal regions of the cerebral cortex compared to cerebellum have markedly different DNA
methylation signatures, with the cerebral cortex being hypermethylated and cerebellum being hypomethylated. Such
differences were observed in distinct genomic regions, including genes involved in CNS function. The MSNP data were
validated for a subset of these genes, by performing bisulfite cloning and sequencing and confirming that prefrontal,
occipital, and temporal cortices are significantly more methylated as compared to the cerebellum."
Sunday, August 15, 2010
Thursday, August 12, 2010
Here's what worked for me:1. Get the IMEI code from your new phone after you charge it all the way. You get this by entering *#06# into the dialer.
2. Get the SIM card unlock code for the HTC Desire from a reputable internet seller. They will need your IMEI.
I used CellUnlock.net and they were very good.
3. Put your Rogers SIM card in the Telus Desire, put in the battery and restart your phone.
4. The Desire will prompt you for the 8 digit SIM unlock code when you try to use it. Enter it.
Now half of it should be working - you should have talk and text. The top right will show how many
bars of signal you have.
5. You will still need to get your data access point connected --
6. On the Desire, make sure Network Mode is set for WCDMA only, or GSM/WCDMA (which is the default).
You will not get data on GSM only. [Go figure.]
7. Enter your new access point name (APN) and settings:
8. Save your new access point name.
9. Try playing with the browser, search or Market. You should see the up and down arrows in the top right corner and now have data too.
Wednesday, August 11, 2010
5 minute podcast here:
"The design principles for the proposed
system included (1) the ability to facilitate nearly instan-
taneous, time-of-service queries of a patient’s entire med-
ical record, on the basis of a clinician’s clinical inference
(eg, “I wonder if condition X is mentioned in this pa-
tient’s record”); (2) the ability to store complex, struc-
tured queries and activate these automatically on the
basis of clinical service schedule or care unit census; (3)
the ability to rapidly filter a patient’s entire EMR data set
to a topic-specified or situation-specified dossier (subset);
and (4) the ability to transmit the output of search either
to readable forms (Web browser) or other software (ma-
The result of these efforts is a system dubbed QPID
(Queriable Patient Inference Dossier), now in use daily
in our department."
Zallis and Harris, J Am Coll Radiol 2010
Tuesday, August 10, 2010
Results from the Duman lab. Will be interesting if replicated.
"Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM. Moreover, adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration. We also found that BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF. "
Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD via #FeedSquares
Nicotinic receptor subunit SNP associated with smoking, COPD, lung cancer.
Sunday, August 8, 2010
Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more. Turner et al.
Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more.
"the multiple first exons represent only a first layer of complexity orchestrated probably by tissue-specific transcription factors. Modulation of alternative first exon activity by epigenetic methylation of their promoters represents a second layer of complexity at least partially controlled by perinatal programming. The alternative promoter usage also appears to affect the 3' splicing generating the different GR coding variants, GRalpha, GRbeta, and GR-P."
Thursday, August 5, 2010
Polymorphic CpG sites can be considered metastable epialleles, are thought to be particularly vulnerable to environmental influences
Tuesday, August 3, 2010
Shi et al. The Pharmacogenomics Journal- Genomic signatures show that classification algorithms choose phenotype-related genes
Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes
by Shi and colleagues:
"A comprehensive analysis of the genes of these signatures and their nonredundant unions using ontology enrichment, biological network building and interactome connectivity analyses demonstrated the link between gene signatures and the biological basis of their predictive power."
Monday, August 2, 2010
"healthy carriers of the CACNA1C risk variant exhibit a pronounced reduction of bilateral hippocampal activation during episodic memory recall and diminished functional coupling between left and right hippocampal regions. Furthermore, risk allele carriers exhibit activation deficits of the subgenual anterior cingulate cortex, a region repeatedly associated with affective disorders and the mediation of adaptive stress-related responses."
This was an fMRI study in 110 healthy subjects:
This SNP was originally associated with Bipolar Disorder, by GWAS.
- Boot time video with SSD.
- Night ride coming up.
- Recommendations for Biomarker Identification and Q...
- pm coffee pic
- Retro Camera pic- rock garden
- Genome-Wide Divergence of DNA Methylation Marks in...
- Syncing music Android (HTC Desire) with Ubuntu 10....
- Unlock @TELUS HTC Desire using Rogers SIM card: ho...
- Advanced Search of the Electronic Medical Record: ...
- Peripheral BDNF Produces Antidepressant-Like Effec...
- Multiple Independent Loci at Chromosome 15q25.1 Af...
- Transcriptional control of the glucocorticoid rece...
- Polymorphic CpG sites can be considered metastable...
- Shi et al. The Pharmacogenomics Journal- Genomic s...
- Arch Gen Psychiatry: CACNA1C allele associated wit...
- ▼ August (15)