Lancet case report, clinical genome. via @TheLancet

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960452-7/fulltext

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Facade -- photo.

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Waterloo's Perimeter Institute. Pic.

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Application of support vector machine modeling for prediction of common diseases: the case of diabetes and pre-diabetes #svm

Yu et al. on machine learning and diabetes phenotypes.

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How to turn your PubMed search into an RSS feed. Via @Berci.

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Functional analysis of a potassium-chloride co-transporter 3 (SLC12A6) promoter polymorphism leading to an additional DNA methylation site.

A study with peripheral lymphocyte DNA.
http://www.ncbi.nlm.nih.gov/pubmed/18536702

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The state of speech recognition in GNU/Linux.

ViaVoice for GNU/Linux was pulled by IBM.
Current/future possiblities might include simon and CMU Sphinx.

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@doctorow's law applied to DRM; a benevolent dictatorship. #iPad

"If someone takes something that belongs to you, and puts a lock on it that you don't have a key for, that lock isn't in your best interests."
"Anytime someone puts a lock on something you own, against your wishes, and doesn't give you the key, they're not doing it for your benefit."
-Cory Doctorow

In his recent Publisher's Weekly article, Cory reviews why "Already, Apple's App Store has displayed the warning signs of a less-than-benevolent dictator."

______________________________________________________________________________________________________________________

http://www.eff.org/deeplinks/2009/04/doctorows-law

http://www.theimaginationage.net/2009/02/doctorows-law.html

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Peaking, on Twitter. Twitter peak times. When does tweeting get more traffic? @tweetoclock

http://www.socialnetworkingtodayblog.com/?tag=best-time-to-tweet

http://thesocialmediaguide.com.au/2010/04/04/when-is-the-best-time-to-tweet/

http://www.garymccaffrey.com/blog/2009/03/19/when-is-the-best-time-to-tweet-for-maximum-twitter-traffic-and-exposure/

http://www.personalbrandingblog.com/30-minute-brand-building-for-twitter/

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RT @moorejh nice @wwwilson Top 10 algorithms in data mining (decided by voting) @myen

Knowl Inf Sys (2008)

http://ow.ly/1C6Ay

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RT @BioMedCentral New software called MochiView published in #BMCBiology allows easier browsing of genomic sequences #OA

http://bit.ly/bVkXiX 

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FASEB Journal: Lymphoblastoid cell lines suggest epigenetic contributions to autism spectrum

Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain

http://www.fasebj.org/cgi/content/abstract/fj.10-154484v1

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altered microRNA expression in autism via @PubMedCentral

"supports the use of the lymphoblasts as a surrogate to study miRNA expression in ASD"

http://bit.ly/bJs6li

http://genomemedicine.com/content/2/4/23/abstract

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Most mammalian mRNAs are conserved targets of microRNAs - via @aemonten

http://genome.cshlp.org/content/19/1/92.full.pdf%2Bhtml

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Anybody tried this one? Voltaic Systems Solar pack.

http://www.voltaicsystems.com/bag_converter.shtml

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Fibroblast Growth Factor-2 Enhances Extinction and Reduces Renewal of Conditioned Fear

"FGF2-treated rats showed less renewal of fear when tested in the original training context than did vehicle-treated rats. This pattern occurred even when vehicle rats were given double the amount of extinction training, and when FGF2-treated rats were given equivalent exposure to the extinction context. These results show that FGF2 facilitates long-term extinction and attenuates relapse, and thus highlight its potential as a novel pharmacological adjunct to exposure therapy."

http://www.nature.com/npp/journal/v35/n6/abs/npp20103a.html

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Lit espresso, on Ronces. Pic. Ymm.

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Last night's late black mirror water ride. Pic.

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Boston Globe on password changing costs, via gizmodo via lifehacker

please_do_not_change_your_password

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Electronic Medical Records -- a boon to data thieves?

http://spectrum.ieee.org/riskfactor/computing/it/electronic-health-records-becoming-a-boon-to-data-thieves?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+IeeeSpectrumComputing+%28IEEE+Spectrum%3A+Computing%29

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RT @NatureNews Picture post: Rosette cloud’s new stars

The European Space Agency’s infrared orbiting telescope Herschel has sent back this image of the Rosette cloud, for your viewing pleasure.

http://blogs.nature.com/news/thegreatbeyond/2010/04/picture_post_rosette_clouds_ne.html

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Anonymization of electronic medical records for validating genome-wide association studies. Vanderbilt. PNAS.

"experiments with real patient data derived from the Vanderbilt's University Medical Center verify that our approach generates data that eliminate the threat of individual reidentification, while supporting GWAS validation and clinical case analysis tasks."

http://www.pnas.org/content/early/2010/04/05/0911686107.abstract

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Epigenetic approaches to complex disorders - via @WRY999

http://www.ncbi.nlm.nih.gov/pubmed/20373664?dopt=Abstract

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Learning about Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700030/?tool=pubmed

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Serving the enterprise and beyond with informatics for integrating biology and the bedside (i2b2). JAMIA

http://www.ncbi.nlm.nih.gov/pubmed/20190053

Software here.

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Increased BDNF promoter methylation in the Wernicke area of suicide subjects.

In post mortem tissue from Wernicke's area, four CpG dinucleotides in the BDNF promoter IV area have elevated methylation in suicide cases compared to controls.

http://www.ncbi.nlm.nih.gov/pubmed/20194826

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Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patients.

http://www.ncbi.nlm.nih.gov/pubmed/20124106

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On acrylamide in food.

http://ehp03.niehs.nih.gov/article/fetchArticle.action?articleURI=info%3Adoi%2F10.1289%2Fehp.118-a160

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Dan Gilbert, psychologist, TED talk on happiness

With references to Shakespeare and Adam Smith. 21 minutes.

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Human Factors "The Usability of Electronic Health Records at Mayo Clinic", podcast+paper

http://www.humanfactors.com/downloads/webcasts.asp

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CMAJ Editor: no more dithering on e-health

http://www.cmaj.ca/cgi/rapidpdf/cmaj.092189v1

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photojournalist James Nachtwey on XDR-TB http://www.xdrtb.org

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Photo, breakfast fruit

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Robust Replication of Genotype-Phenotype Associations across Multiple Diseases in an Electronic Medical Record (AJHG)

Ritchie et al., Vanderbilt:

"phenotypes representing clinical diagnoses can be extracted from EMR systems, and they support the use of DNA resources coupled to EMR systems as tools for rapid generation of large data sets required for replication of associations found in research cohorts and for discovery in genome science"

http://www.cell.com/AJHG/abstract/S0002-9297%2810%2900146-1

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Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain (AJHG)

"DNA methylation is frequently a heritable continuous quantitatively variable trait in human brain"

http://www.cell.com/AJHG/abstract/S0002-9297%2810%2900087-X

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