Hu et al.

SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk of genetic epistasis in bipolar disorder.

Hu and colleagues developed a method for analyzing epistasis in a GWAS of complex traits, and exclude the contamination of marginal effects caused by single-locus association. They analyzed the Wellcome Trust Case Control Consortium's (WTCCC) bipolar disorder GWAS data.

http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201068a.html

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