Active DNA demethylation in human postmitotic cells correlates with activating histone modifications, but not transcription levels

"Using a global, comparative CpG methylation profiling approach we identified many novel examples of active DNA demethylation and characterised accompanying transcriptional and epigenetic events at these sites during monocytic differentiation. We show that active DNA demethylation is not restricted to proximal promoters and that the time-course of demethylation varies for individual CpGs."

http://genomebiology.com/2010/11/6/R63/abstract

Posted via email from the nocx files