Saturday, December 4, 2010

Early life stress enhances vulnerability to stress via activation of REST4-mediated gene transcription

Rat pups separated from their mothers:

1) Have increased depressive-like and anhedonic behaviours
2) Show an increased expression of the neuron-specific transcriptional repressor REST4 in the medial prefrontal cortex
3) Gene transfer induced REST4 overexpression in the medial prefrontal cortex increased vulnerability to stress

J Neurosci
Yamaguchi University

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