Reversal of Depressed Behaviors in Mice by p11 Gene Therapy

Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens

Alexander et al. (STM, 2010) state: "These results suggest that p11 loss in rodent and human nucleus accumbens may contribute to the pathophysiology of depression. Normalization of p11 expression within this brain region with AAV-mediated gene therapy may be of therapeutic value. "

http://stm.sciencemag.org/content/2/54/54ra76.short?etoc

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