Thursday, September 2, 2010

Epigenetic Transmission of the Impact of Early Stress Across Generations [via @thinkgenome]

After stressing postnatal mice for days 1-14 --

"chronic and unpredictable maternal separation induces depressive-like behaviors and alters the behavioral response to aversive environments in the separated animals when adult. Most of the behavioral alterations are further expressed by the offspring of males subjected to maternal separation, despite the fact that these males are reared normally. Chronic and unpredictable maternal separation also alters the profile of DNA methylation in the promoter of several candidate genes in the germline of the separated males. Comparable changes in DNA methylation are also present in the brain of the offspring and are associated with altered gene expression."

Posted via email from nocx

No comments: