Dynamic instability of genomic methylation patterns in pluripotent stem cells #epigenetics #stemcells

Ooi and colleagues conclude:

"Error-prone maintenance methylation will introduce unpredictable phenotypic variation into clonal populations of pluripotent stem cells, and this variation is likely to be much more pronounced in cultured female cells. This epigenetic variability has obvious negative implications for the clinical applications of stem cells."

 Implications for complex phenotypes?

http://www.epigeneticsandchromatin.com/content/3/1/17

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