Epigenetics of Bipolar disorder
T. Kato
Previous association studies:
Ferreira et al Nat Genet 2008
PBRM1 Nat Genet 2010
GAD1
GABA A R alpha 1
COX10
RELN
MZ discordance for bipolar disorder:
1. Point mustation
2. CNV
3. mosaicism
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Methods - unbiased approach RED, RAPD, RDA, MS-RDA
Two pairs MZ twins discordant for bipolar disorder
488K CNV
MBD2B MBD3L1 conjugated beads Active Motif
Tiling arrays
Promoter wide DNA methylation analysis p<10^-4 by MAT
Bisulfite sequencing of 13 regions overlapping with CpG island to validate; refined p<10^-6
HTTLPR DMR upstream 25,590,000(?correct location -- nocx not sure about this position) -- seen in ss genotype only
Beach 2010, van IJzendoorn Biol Psy 2010
Philibert group 2010 SLC6A4 papers
see also poster 2527W Hiroko Sugawara
Posted via email from nocx
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