Monday, May 24, 2010

GREAT improves functional interpretation of cis-regulatory regions, via @thinkgenome

'Genomic Regions Enrichment of Annotations Tool' 
Mclean et al. 
Nat Biotechnol 28:495–501 2010

The software completes an analysis showing which genes a transcription factor is likely to influence, and the relevant molecular pathways, across the genome.  It incorporates proximal and distal binding and controls for false positives using a binomial test.

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