Fibroblast Growth Factor-2 Enhances Extinction and Reduces Renewal of Conditioned Fear

"FGF2-treated rats showed less renewal of fear when tested in the original training context than did vehicle-treated rats. This pattern occurred even when vehicle rats were given double the amount of extinction training, and when FGF2-treated rats were given equivalent exposure to the extinction context. These results show that FGF2 facilitates long-term extinction and attenuates relapse, and thus highlight its potential as a novel pharmacological adjunct to exposure therapy."

http://www.nature.com/npp/journal/v35/n6/abs/npp20103a.html

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