Pharmacogenomics: Is miRNA the future of phenotyping?

MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.

You can get the paper here

Posted via email from the nocx files

Endurance training enhances BDNF release from the human brain #guam

http://www.ncbi.nlm.nih.gov/pubmed/19923361

Posted via email from the nocx files

Proc Royal Soc B: Oxytocin, stress, mothers talking to daughters

Seltzer et al. 

Social vocalizations can release oxytocin in humans, via @CynthiaHenrich

http://rspb.royalsocietypublishing.org/content/early/2010/05/06/rspb.2010.0567.short?rss=1

Posted via email from the nocx files

Extensive sequence-influenced DNA methylation polymorphism in the human genome

Hellman and Chess: Methylation is not independent of SNPs.

http://www.epigeneticsandchromatin.com/content/3/1/11

Posted via email from the nocx files

GREAT improves functional interpretation of cis-regulatory regions, via @thinkgenome

'Genomic Regions Enrichment of Annotations Tool' 

Mclean et al. 

Nat Biotechnol 28:495–501 2010

The software completes an analysis showing which genes a transcription factor is likely to influence, and the relevant molecular pathways, across the genome.  It incorporates proximal and distal binding and controls for false positives using a binomial test.

http://www.nature.com/nbt/journal/v28/n5/abs/nbt.1630.html

GREAT website.

Posted via email from the nocx files

Anonymization of electronic medical records for validating genome-wide association studies

The "approach automatically extracts potentially linkable clinical features and modifies them in a way that they can no longer be used to link a genomic sequence to a small number of patients, while preserving the associations between genomic sequences and specific sets of clinical features corresponding to GWAS-related diseases."

http://www.pnas.org/content/early/2010/04/05/0911686107.abstract

Posted via email from the nocx files

RNA transcripts from "junk DNA" - how abundant are they, really? via @NatureNews

Paper here.

Editorials --

http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000370

http://www.nature.com/news/2010/100518/full/news.2010.248.html?s=news_rss#B5

Posted via email from the nocx files