tag:blogger.com,1999:blog-43031956861935141942011-09-28T11:16:48.183-07:00Beginner's Ridenocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.comBlogger2141100tag:blogger.com,1999:blog-4303195686193514194.post-72883521006759567972010-12-31T07:11:00.001-08:002010-12-31T07:11:40.345-08:00<div class='posterous_autopost'><div>I was able to put a decent dent in the ever-growing &quot;to read&quot; pile over the last year.  ALL of these are worth reading at least once, many of them would bear a second reading (esp. Borges, Murakami, Gibson, Beukes, Bolano, Tatsumi).  Zero History was read mostly on my phone, as were parts of The Wind-Up Bird Chronicle.  </div> <p />MAKERS                             Cory Doctorow<div>The Savage Detectives         Roberto Bolano</div><div>Zoo City                               Lauren Beukes</div><div>Zero History                         William Gibson</div> <div>The Wind-Up Bird Chronicle   Haruki Murakami</div><div>Marshall McLuhan                 Douglas Coupland</div><div>Labyrinths (first half)             Jorge L. Borges  </div><div>Black Blizzard                      Yoshihiro Tatsumi</div> <div>A Drifting Life                       Yoshihiro Tatsumi</div><div>The Paradox of Choice          Barry Schwartz</div></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7288352100675956797?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-61751493955821589922010-12-04T17:22:00.001-08:002010-12-04T17:24:33.814-08:00<div class="posterous_autopost">Rat pups separated from their mothers:<br /><div><br /><div>1) Have increased depressive-like and anhedonic behaviours</div><div>2) Show an increased expression of the neuron-specific transcriptional repressor REST4 in the medial prefrontal cortex</div><div>3) Gene transfer induced REST4 overexpression&nbsp;in the medial prefrontal cortex&nbsp;increased vulnerability to stress<br /><br /></div></div><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/21068306">Uchida et al. 2010</a></div><div>J Neurosci</div><div>Yamaguchi University</div></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6175149395582158992?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-3330412623700166232010-11-24T18:41:00.001-08:002010-11-24T18:41:41.283-08:00<div class='posterous_autopost'><div>Interesting abstract -</div><a href="http://www.nature.com/ng/journal/v42/n12/abs/ng.708.html">http://www.nature.com/ng/journal/v42/n12/abs/ng.708.html</a></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-333041262370016623?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-57405798479531492502010-11-14T14:06:00.001-08:002010-11-14T14:06:23.027-08:00<div class='posterous_autopost'><div><b>J. Kamal  Ohio State UMC data warehouse </b></div><div><b></b>13+ year project</div><div>Information Warehouse - IW</div><div>IW Data Marts: Business, Clinical, Research, External</div><div>Started with financial. </div> <div>Web scorecards, dashboards, NLP, data mining.</div><div>Powerful ad hoc query tools.</div><div>Oracle BI Discoverer.</div><div>iCount - User Query tool for aggregates -- aggregate counts of patient cohorts to define patient populations for research grants; tied to standard terminology; all users have access. No IRB needed.</div> <div>IW has &gt;4K users </div><div>Queries increasing exponentially.</div><div>Users: Administrators, managers, clinicinas researchers, finance.</div><div>50 dashboards of approx 1K indicators. Powerful visual reports.</div> <div>Research portal, Investigator profile</div><div>CIO dashboard.</div><div>MRSA reporting</div><div>Antimicrobial</div><div>Restraint Orders</div><div>Falls</div><div>Diabetes mgmt</div><div>Genetic data storage and analysis</div> <div>Patient tracker automates patient flow recording</div><div>Managers notified of idle processes</div><p /><div>Data driven issue awareness</div><div>More scorecards</div><div>Physician Profiling system</div> <div>De-identified IW</div><div>Hagop Mekhjian MD Chief Medical Officer</div><div>Posters 14, 41, 102, 46, 91, ... (11+ posters)</div><div>IW at OSUMC has Honest Broker status; Two protocols - internal+ external - worked with IRB and Research Office to </div> <div>make processes robustly meet the criteria for non-human subject research.</div><p /><p /><p /><div><b>C. Weng et al. Comparing Effectiveness of Clinical Registry vs. Clinical Data Warehouse for Supporting Clinical Trial Recruitment: Case Study</b></div> <div>Columbia University</div><div>TECOS Trial Evaluating Cardiovasc Outcomes w Sitagliptin</div><p /><div>Diabetes Registry created in 2005, contains 5K patients, few variables A1C, urine microalb., LDL chol</div> <div>vs. </div><div>Clinical Data Warehouse</div><div>Too many false positives recruiting with Registry, PI turned to Informatics/Data Warehouse</div><div>Warehouse had 2X the # of variables of interest vs. Registry (8/12 vs. 4/12).</div> <div>Temporarily Ineligible (awaiting result)</div><div>Definitely Ineligible</div><div>Potentially Eligible &gt; recent visit, must be referred by their primary care provider.</div><div>Confirmed Eligible</div><div>Target n=60</div> <div>                                 Registry        Warehouse</div><div>Potentially Eligible        2033             100   </div><div>Confirmed Eligible            29(6.6%)     31 (31%)</div><div>nonconsent rate                 S  i  m  i  l  a  r</div> <div>No working days               74              59</div><div>Patients/wk                        1              2.5</div><div>Total in 3 months              14              30  </div><p /><div>Registry lacked rich clinical data for evaluating exclusion criteria</div> <div>Columbia Study site rated #3 of over 300+ sites worldwide.</div><div>Warehouse needs sophisticated query skills.</div><div>Registry has better quality for disease-specific markers.</div><div>CDW  more effective in excluding the ineligible.</div> <div>Dynamically generated registries linked to CDW can lead to promising recruitment solutions,</div><div>Planning a dynamic Protocol-specific screening tool that utilizes CDW and Registry</div><div>PI Weng NLM R01 </div> <div><a href="mailto:cw2384@columbia.edu">cw2384@columbia.edu</a></div><p /><p /><p /><div><b>Payne P. TRITON Project</b></div><div><b>Integrative Translational Research Information Management Platform</b></div> <div>CLL Research Consortium</div><div>NCI funded P01 fo rCLL</div><div>n=5,000 cohort</div><p /><div>Objectives:</div><div>Modernize legacy information system</div><div>provide tools to increase in research productivity</div> <div>-data exchange</div><div>-bio-specimen mgmt</div><div>-adverse event detection</div><div>-protocol driven Decision support</div><div>-integraitve query and data aggregation</div><div>Provide community access to technologyes</div> <p /><div>Systems Design:</div><div>Open source, standards compliant</div><div>portal based approach</div><div>caTissue</div><div>caAERS</div><div>caGRID</div><div>SQL</div><div>MySQL</div><div>GWT environment &quot;Google look and feel&quot;</div> <div>Current Project Status</div><p /><div>billing, budgeting, trial mgmt, close-out and reporting</div><p /><div>Model-driven design/architecture:</div><div>Real world protocols &gt; represent as a logical model&gt;map to standards and data sources</div> <p /><div>Some lessons:</div><div>Don&#39;t use just PIs - get research staff &quot;on the ground&quot;.</div><div>Use Project Management methods.</div><div>Organization perception is just as important as technical functionality. </div> <div><a href="http://crcwiki.ucsd.edu">crcwiki.ucsd.edu</a></div><div><a href="mailto:philip.payne@osumc.edu">philip.payne@osumc.edu</a></div><p /><p /><p /><div><b>Mining Clinical Data using Minimal Predictive Rules</b></div> <div><b>Batal I. and Hauskrecht M., University of Pittsburgh</b></div><div>Rule Induction methods represent knowledge</div><div>Association Rules more complete than greedy algorithsm - eg. trees; generate a lot of rules</div> <div>Add correlation measure - statistical test or interestingness measure (evaluates each rule individually</div><div>We should consider the nested structure of the rules.</div><div>Minimal Predictive Rule [MPR]:</div><div> predicts class significantly better than the subrules</div><div>Lossy pruning speeds the mining, at the risk of some missing MPRs.</div><div>A-MPR prunes 98% of the search space without changing AUC.</div><div>An efficient algorithm for approximate mining.</div></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5740579847953149250?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-85631079059483362062010-11-13T12:09:00.001-08:002010-11-13T12:09:27.718-08:00<div class='posterous_autopost'><a href="http://prezi.com/hgjm18z36h75/why-should-you-move-beyond-slides/">http://prezi.com/hgjm18z36h75/why-should-you-move-beyond-slides/</a></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8563107905948336206?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-61760663603697676832010-11-05T13:07:00.001-07:002010-11-05T13:07:57.805-07:00<div class='posterous_autopost'><div>Epigenetics of Bipolar disorder</div><div>T. Kato</div><p /><div>Previous association studies:</div><div>Ferreira et al Nat Genet 2008</div><div>PBRM1 Nat Genet 2010</div><div>GAD1</div><div>GABA A R alpha 1</div> <div>COX10</div><div>RELN</div><p /><div>MZ discordance for bipolar disorder:</div><div>1. Point mustation</div><div>2. CNV</div><div>3. mosaicism</div><div>.</div><div>.</div><div>.</div><p /><div>Methods - unbiased approach RED, RAPD, RDA, MS-RDA</div> <div>Two pairs MZ twins discordant for bipolar disorder</div><div>488K CNV</div><div>MBD2B MBD3L1 conjugated beads Active Motif</div><div>Tiling arrays</div><p /><div>Promoter wide DNA methylation analysis p&lt;10^-4 by MAT</div> <div>Bisulfite sequencing of 13 regions overlapping with CpG island to validate; refined p&lt;10^-6 </div><div>HTTLPR DMR upstream 25,590,000(?correct location -- nocx not sure about this position) -- seen in ss genotype only</div> <div>Beach 2010, van <span style="font-family: arial, sans-serif; line-height: 15px;"> IJzendoorn</span> Biol Psy 2010</div><div> Philibert group 2010 SLC6A4 papers</div><div>see also poster 2527W Hiroko Sugawara</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/t-kato-on-epigenetics-of-bipolar-disorder-ash">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6176066360369767683?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-39404072545237603852010-11-03T21:37:00.001-07:002010-11-03T21:37:43.376-07:00<div class='posterous_autopost'><div>Divya Mehta  et al</div><div>Polymorphisms in FKBPS define biologically distinct subtypes of PTSD: evidence from endocrine and gene expression studies</div><p /><div>Individuals with PTSD have supersensitive GR.</div> <div>FKBP5 is a cochaperone, part of a mature heteroGR complex, and regulator of the heteroGR complex.</div><div>FKBP5 SNPs interact with child abuse to predict PTSD symptoms. </div><div>Binder et al. 2008; Yehuda group paper.</div> <p /><div>African American sample from suburban Atlanta.</div><div>218 participants with trauma history.</div><div>PSS (PTSD measure)</div><div>183 transcripts associated with trauma scores, none previously described.</div> <div>Then they stratified transcript results by genotype*PTSD --significant interaction, no main effect.</div><div>32 significant interactions, transcripts previously identified, associated with PTSD symptoms X FKBP5 SNP rs 92950158.</div> <div>Opposite effects of transcripts in carriers of risk and protective markers.</div><p /><div>Complmented with a literature based - pathway mining approach. </div><div>Use intermediate phenotypes.</div><div>use co-expression networks.</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/d-mehta-polymorphisms-in-fkbps-define-biologi">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3940407254523760385?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-16141345030894427342010-11-03T21:32:00.001-07:002010-11-03T21:32:17.625-07:00<div class='posterous_autopost'><div>Follow up to GWAS:</div><div>Sequence regions near most significant SNPs, sequence all local genes </div><p /><div>Transcriptome studies using lymphoblastoid cell lines -  PLoS Genetics 2010</div> <div>SNPs with highest eQTLs are enriched for WTCCC Crohn&#39;s susceptibility loci</div><div>+other loci too. Pattern different in CAD, Hypertension, T2D.</div><div>Enrichment of locally acting eQTLs versus distantly acting eQTLs.</div> <div>T2D had most dramatic enrichment in a late bin-- transcriptome studies using adipose and muscle tissue.</div><div>Most QTLs are distant regulators of gene expression.</div><div>Took top 1K SNPs in WTCCC T2D studies. Vast majority enriched for eQTLs acting distantly.</div> <div>Cancer mostly local regulators.</div><div>T1D more local than distant.</div><div>Distant regulators quite often on different chromosomes.</div><div>Will different phenotypes have different architecture WRT distant vs. local regulators?</div> <div>Does tissue specificitiy play a role?</div><div>Has implications for how we think about sequencing studies.</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/nancy-cox-are-we-looking-in-the-wrong-places">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1614134503089442734?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-51743329459735147372010-11-03T21:30:00.001-07:002010-11-03T21:30:36.509-07:00<div class='posterous_autopost'><div>RNA-DNA differences = RDD</div><div>RDD are not traditional RNA editing or transcription infidelity</div><div>n=27 CEU</div><div>RNA sequences of B cells</div><div>DNA sequences from publicly available</div><div>Each person has 3.8K RDDs+/-1.6K</div> <div>20K RDD sites in 4500 genes</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/mingyao-li-plenary-on-rna-editing-ashg2010">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5174332945973514737?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-63806877796388699112010-10-31T14:17:00.001-07:002010-10-31T14:40:38.649-07:00<div class="posterous_autopost">It started as an experiment. <br /><div>Over the past twelve months Ubuntu it stopped being an experiment and became my modus operandi.<br /><div>Was there a singular epiphany for me? &nbsp;I don't think so. &nbsp;It felt more like watching the sun rise a few times,&nbsp;with each installation. &nbsp;On my notebook, I've done fresh installs of Karmic and Lucid; and the Meerkat upgrade. &nbsp;My daughter has UNE on her netbook.</div><div><div><div><div>Many thanks to the Ubuntu community. &nbsp;</div><div><div><div><object height="300" width="500"><param name="movie" value="http://www.youtube.com/v/4b0bog2bbvg?fs=1&amp;hl=en_US" /><param name="allowFullScreen" value="true" /><param name="allowscriptaccess" value="always" /><embed allowfullscreen="true" src="http://www.youtube.com/v/4b0bog2bbvg?fs=1&hl=en_US" allowscriptaccess="always" type="application/x-shockwave-flash" height="300" width="500"></embed></object></div></div></div></div></div></div></div><div style="font-size: 10px;"><a href="http://posterous.com/">Posted via email</a> from <a href="http://nocx.posterous.com/just-had-coffee-celebrating-my-first-year-of">nocx</a> </div></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6380687779638869911?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-7818147335290982262010-10-22T07:53:00.001-07:002010-10-22T07:53:47.189-07:00<div class='posterous_autopost'><h2><span style="font-weight: normal;"><span style="font-size: small;"><a href="http://www.nature.com/ejhg/journal/v18/n11/abs/ejhg201092a.html">Genes predict village of origin in rural Europe</a></span></span></h2> <div><span style="font-weight: normal;">O&#39;Dushlaine et al. Eur J Hum Genet 2010</span></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/dna-as-historical-gps">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-781814733529098226?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-15688846152695273042010-10-22T07:28:00.001-07:002010-10-22T07:28:12.784-07:00<div class='posterous_autopost'><h2><span style="font-weight: normal;"><span style="font-size: small;">Haworth et al. </span></span><span style="font-weight: normal; font-size: small;">Mol Psy 2010</span></h2> <h2><span style="font-weight: normal; font-size: small;"><a href="http://www.nature.com/mp/journal/v15/n11/abs/mp200955a.html">A study of 11,000 twin pairs from four countries.</a></span></h2> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/the-heritability-of-general-cognitive-ability">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1568884615269527304?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-51073684929803073912010-10-20T20:18:00.001-07:002010-10-20T20:18:42.185-07:00<div class='posterous_autopost'><span class="cit-title">Implantable Microbeads for Continuous Glucose Monitoring </span><p /><a href="http://stm.sciencemag.org/content/2/54/54ec164.short?etoc">http://stm.sciencemag.org/content/2/54/54ec164.short?etoc</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/fewer-sticks-for-diabetics-microbead-glucose">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5107368492980307391?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-23130074266231168602010-10-20T20:14:00.001-07:002010-10-20T20:14:33.371-07:00<div class='posterous_autopost'><h1 style="font-weight: normal;">Reversal of Depressed Behaviors in Mice by p11 Gene Therapy in the Nucleus Accumbens</h1>Alexander et al. (STM, 2010) state: &quot;These results suggest that p11 loss in rodent and human nucleus accumbens may contribute to the pathophysiology of depression. Normalization of p11 expression within this brain region with AAV-mediated gene therapy may be of therapeutic value. &quot;<p /><a href="http://stm.sciencemag.org/content/2/54/54ra76.short?etoc">http://stm.sciencemag.org/content/2/54/54ra76.short?etoc</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/reversal-of-depressed-behaviors-in-mice-by-p1">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2313007426623116860?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-7154342654861330562010-10-18T19:44:00.001-07:002010-10-18T19:44:25.926-07:00<div class='posterous_autopost'><a href="http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2219.html">http://www.nature.com/nm/journal/vaop/ncurrent/full/nm.2219.html</a><p /> <div>MAP kinase phosphatase 1 (MKP-1) /DUSP1.</div><div>Another study that points to this pathway, from the lab of Ron Duman.</div><div>Expression study in human post-mortem MDD brain and rat and mouse models. </div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/nature-medicine-negative-regulator-of-map-kin">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-715434265486133056?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-72362785272065018302010-10-15T10:32:00.001-07:002010-10-18T18:37:10.363-07:00<div class="posterous_autopost"><div>The recent meta-analysis in the British Medical Journal says Reboxetine is "ineffective and potentially harmful". &nbsp;Publication bias evident.</div><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/20940209">http://www.ncbi.nlm.nih.gov/pubmed/20940209</a></div><a href="http://www.medscape.com/viewarticle/730537">http://www.medscape.com/viewarticle/730537</a> <br /><div style="font-size: 10px;"><a href="http://posterous.com/">Posted via email</a> from <a href="http://nocx.posterous.com/reboxitine-meta-analysis-calls-into-question">nocx</a> </div></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7236278527206501830?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-69362937765401425372010-10-11T19:49:00.001-07:002010-10-11T19:49:25.321-07:00<div class='posterous_autopost'><div>Cheung et al. PLoS Biology 2010</div><p /><div>Polymorphic cis- and trans-regulation of human gene expression</div><p /><div><span style="font-family: arial, helvetica, sans-serif; line-height: 18px;">&quot;The majority of the regulators act in trans to the target (regulated) genes. Most of these trans-regulators were not known to play a role in gene expression regulation. The identification of these regulators enabled the characterization of polymorphic regulation of human gene expression at a resolution that was unattainable in the past.&quot;</span></div> <p /><a href="http://www.ncbi.nlm.nih.gov/pubmed/20856902">http://www.ncbi.nlm.nih.gov/pubmed/20856902</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/genetics-of-gene-expression-goge-recent-paper">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6936293776540142537?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-7123280656584886072010-10-04T06:44:00.001-07:002010-10-04T06:44:15.611-07:00<div class='posterous_autopost'><div><h1 class="title"><span style="font-weight: normal; font-size: small;" /></h1><h1 class="title"><span style="font-weight: normal;"><span style="font-size: small;">Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample</span></span></h1> </div><div>Uddin et al. use bioinformatic analyses and find genome-wide methylation profiles differ between depressed individuals and controls.</div><p /><a href="http://www.ncbi.nlm.nih.gov/pubmed/20836906">http://www.ncbi.nlm.nih.gov/pubmed/20836906</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/epigenetic-and-inflammatory-marker-profiles-a">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-712328065658488607?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-12473322298693734812010-10-02T16:59:00.001-07:002010-10-02T16:59:10.695-07:00<div class='posterous_autopost'>Allele-specific methylation is quantitative and heterogeneous, and increases genetic complexity of associations between loci and complex disease--<br /><p /><div>Meaburn et al. <i>Epigenetics 2010</i></div><p /><div><a href="http://www.landesbioscience.com/journals/epigenetics/article/12960">http://www.landesbioscience.com/journals/epigenetics/article/12960</a></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/allele-specific-methylation-in-the-human-geno">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1247332229869373481?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-14254579196159361422010-09-27T08:49:00.001-07:002010-09-27T08:49:32.486-07:00<div class='posterous_autopost'><div style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;"><div><div style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;">Ooi and colleagues conclude:</div></div> <p /></div>&quot;Error-prone maintenance methylation will introduce unpredictable phenotypic variation into clonal populations of pluripotent stem cells, and this variation is likely to be much more pronounced in cultured female cells. This epigenetic variability has obvious negative implications for the clinical applications of stem cells.&quot;<p /><div><span style="font-size: 12px; line-height: 18px;"> Implications for complex phenotypes?<br /> </span><p /><div><a href="http://www.epigeneticsandchromatin.com/content/3/1/17">http://www.epigeneticsandchromatin.com/content/3/1/17</a></div></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/dynamic-instability-of-genomic-methylation-pa">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1425457919615936142?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-10063473042741960782010-09-22T10:46:00.001-07:002010-09-22T10:46:56.014-07:00<div class='posterous_autopost'><div>This study examines blood and regional brain BDNF concentrations in rats, pigs and mice.</div><p /><a href="http://www.ncbi.nlm.nih.gov/pubmed/20604989">http://www.ncbi.nlm.nih.gov/pubmed/20604989</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/blood-bdnf-concentrations-reflect-brain-tissu">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1006347304274196078?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-78887882740182108292010-09-21T07:41:00.001-07:002010-09-21T07:41:15.838-07:00<div class='posterous_autopost'><div>JAMIA recently published a study which shows that EMR can be utilized to characterize phenocopies, phenotypic heterogeneity, and important related variables to support GWAS.  Their evidence supports the use of EMR-linked biorepositories for GWAS. </div> <p /><div><a href="http://jamia.bmj.com/content/17/5/568.abstract">Kullo and colleagues&#39; abstract here</a>.</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/liked-amiainformatix-emr-enabled-gwas-on-peri">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7888788274018210829?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-83700212356373903372010-09-21T07:26:00.001-07:002010-09-21T07:26:08.897-07:00<div class='posterous_autopost'><div><div><span style="font-family: arial, helvetica, sans-serif;">. . . and the relevance of Kasparov&#39;s experiment to medical informatics.</span></div> </div><p /><div><span style="font-family: arial, helvetica, sans-serif;">Note on Friedman&#39;s ‘fundamental theorem of biomedical informatics’</span></div> <div><a href="http://jamia.bmj.com/content/17/5/614.extract">http://jamia.bmj.com/content/17/5/614.extract</a></div><p /><p /><div><span style="font-family: arial, helvetica, sans-serif;">‘Their skill at manipulating and “coaching” their computers to look very deeply into positions effectively counteracted the superior chess understanding of their grandmaster opponents and the greater computational power of other participants. Weak human + machine + better process was superior to a strong computer alone and, more remarkably, superior to a strong human + machine + inferior process.’ - Kasparov</span></div> <div><a href="http://www.nybooks.com/articles/archives/2010/feb/11/the-chess-master-and-the-computer/?page=1">http://www.nybooks.com/articles/archives/2010/feb/11/the-chess-master-and-the-computer/?page=1</a> </div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/in-which-s-mani-discusses-kasparovs-experimen">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8370021235637390337?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-66787868493738081362010-09-20T11:12:00.001-07:002010-09-20T11:30:11.733-07:00<div class="posterous_autopost"><span style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16px;"></span><br /><span style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 11px; line-height: 16px;"><h1 style="border-bottom-style: none; border-color: initial; border-color: initial; border-left-style: none; border-right-style: none; border-top-style: none; clear: both; font-family: inherit; font-style: inherit; line-height: 1.2em; margin-bottom: 0px; margin-left: 0px; margin-right: 0px; margin-top: 0px; padding-bottom: 0px; padding-left: 0px; padding-right: 0px; padding-top: 0px; vertical-align: baseline;"><span style="font-size: small;"><span style="font-weight: normal;">Genetics of childhood and adolescent depression: insights into etiological heterogeneity and challenges for future genomic research</span></span></h1><div><span style="font-weight: normal;"><span style="font-size: small;">Rice and colleagues have used a&nbsp;</span></span><span style="font-family: arial, helvetica, sans-serif; line-height: 18px;"><span style="font-size: small;">"prenatal cross-fostering' design where pregnant mothers are related or unrelated to their child as a result of in vitro fertilization (IVF) was used to disentangle maternally inherited and environmental influences.</span></span><span style="font-size: small;">"</span></div><div><span style="font-size: small;">They have noted "</span><span style="font-family: arial, helvetica, sans-serif; line-height: 18px;"><span style="font-size: small;">Associations between prenatal stress and offspring birth weight, gestational age and antisocial behaviour were seen in both related and unrelated mother-offspring pairs, consistent with there being environmental links. The association between prenatal stress and offspring anxiety in related and unrelated groups appeared to be due to current maternal anxiety/depression rather than prenatal stress. In contrast, the link between prenatal stress and offspring attention deficit hyperactivity disorder was only present in related mother-offspring pairs and therefore was attributable to inherited factors.</span></span><span style="font-size: small;">"</span><br /><span style="font-size: small;"><br /></span><br /><span style="font-size: small;"><span class="Apple-style-span" style="font-size: small;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/19476689">http://www.ncbi.nlm.nih.gov/pubmed/19476689</a></span></span></div><div style="font-size: 10px;"><a href="http://posterous.com/">Posted via email</a> from <a href="http://nocx.posterous.com/heritability-of-childhoodadolescent-depressio">nocx</a> </div></span></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6678786849373808136?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-88794294284223518162010-09-15T16:27:00.001-07:002010-09-15T16:27:30.360-07:00<div class='posterous_autopost'><div>Feinberg et al from <i>Sci Transl Med --</i></div><p /><div>&quot;an unbiased genome-scale analysis of ~4 million CpG sites in 74 individuals with comprehensive array-based relative methylation (CHARM) analysis. We found 227 regions that showed extreme interindividual variability [variably methylated regions (VMRs)] across the genome, which are enriched for developmental genes based on Gene Ontology analysis. Furthermore, half of these VMRs were stable within individuals over an average of 11 years, and these VMRs defined a personalized epigenomic signature. Four of these VMRs showed covariation with body mass index consistently at two study visits and were located in or near genes previously implicated in regulating body weight or diabetes.&quot;</div><p /><a href="http://stm.sciencemag.org/content/2/49/49ra67.short?etoc">http://stm.sciencemag.org/content/2/49/49ra67.short?etoc</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/personalized-epigenomic-signatures-that-are-s">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8879429428422351816?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-21476623398364984582010-09-15T07:05:00.001-07:002010-09-15T07:05:34.283-07:00<div class='posterous_autopost'><div><h1><span style="font-size: small;"><span style="font-weight: normal;">Candidate gene prioritization by network analysis of differential expression using machine learning approaches</span></span></h1> </div><p /><div><span style="font-size: small;"><span style="font-weight: normal;">Using three of their own strategies to analyze gene expression scores versus Simple Expression Ranking, the </span></span></div> <div><span style="font-size: small;"><span style="font-weight: normal;">authors found:</span></span></div><p /><div><span style="font-size: small;"><span style="font-weight: normal;">&quot; </span></span></div><div>Our results showed that our four strategies could outperform this standard procedure and that the best results were obtained using the Heat Kernel Diffusion Ranking leading to an average ranking position of 8 out of 100 genes, an AUC value of 92.3% and an error reduction of 52.8% relative to the standard procedure approach which ranked the knockout gene in average at position 17 with an AUC value of 83.7%.</div><div>&quot;</div><a href="http://www.biomedcentral.com/1471-2105/11/460/abstract">http://www.biomedcentral.com/1471-2105/11/460/abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/network-analysis-of-differential-expression-u">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2147662339836498458?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-22830100545636408192010-09-04T21:02:00.001-07:002010-09-04T21:02:52.606-07:00<div class='posterous_autopost'><div><span style="font-family: arial, helvetica, sans-serif; line-height: 18px;">&quot;We observed the presence of DNA demethylation activity, which was increased in FC nuclear extracts from mice treated with valproate (VPA, 2.2 mmol/kg, twice a day for 3 days). VPA not only reduces anxiety and cognitive deficits and other symptoms in bipolar disorder (BP) disorder and schizophrenia (SZ) patients but also upregulates Reln and glutamic acid decarboxylase 67 (Gad67) mRNA/protein expression by reducing the methylation of their promoters. We believe that the identification of an enzyme in brain that facilitates DNA-demethylation and an understanding of how drugs induce DNA demethylation are crucial to progress in a new line of pharmacological interventions to treat neurodevelopment, neuropsychiatric and neurodegenerative diseases.&quot;</span></div> <p /><div><span style="font-family: arial, helvetica, sans-serif; line-height: 15px;"><a href="" title="Epigenetics : official journal of the DNA Methylation Society." style="color: black; font-weight: normal; border-bottom-width: 1px; border-bottom-style: dotted; border-bottom-color: black; text-decoration: none;">Dong et al. Epigenetics.</a> 2010 Nov 16;5(8). [Epub ahead of print]</span></div> <p /><a href="http://www.ncbi.nlm.nih.gov/pubmed/20716949">http://www.ncbi.nlm.nih.gov/pubmed/20716949</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/valproate-induces-dna-demethylation-in-nuclea">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2283010054563640819?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-30202712340367835892010-09-02T06:52:00.001-07:002010-09-02T06:52:29.426-07:00<div class='posterous_autopost'><div style="font-size: 11px; line-height: 14px;"><div style="font-family: helvetica, arial, sans-serif; line-height: normal; font-size: 13px;"><div> After stressing postnatal mice for days 1-14 --</div><p /></div></div>&quot;chronic and unpredictable maternal separation induces depressive-like behaviors and alters the behavioral response to aversive environments in the separated animals when adult. Most of the behavioral alterations are further expressed by the offspring of males subjected to maternal separation, despite the fact that these males are reared normally. Chronic and unpredictable maternal separation also alters the profile of DNA methylation in the promoter of several candidate genes in the germline of the separated males. Comparable changes in DNA methylation are also present in the brain of the offspring and are associated with altered gene expression.&quot;<p /><div><span style="font-size: 11px; line-height: 14px;"><span style="font-family: helvetica, arial, sans-serif; line-height: normal; font-size: 13px;"><a href="http://www.biologicalpsychiatryjournal.com/article/PIIS0006322310005767/fulltext">Franklin et al. Biol Psychiatry 2010</a></span></span></div> <p /><div><span style="font-size: 11px; line-height: 14px;"><span style="font-family: helvetica, arial, sans-serif; line-height: normal; font-size: 13px;"><a href="http://insciences.org/article.php?article_id=9468">More here.</a></span></span></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/epigenetic-transmission-of-the-impact-of-earl">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3020271234036783589?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-29237211629190037032010-08-27T10:21:00.001-07:002010-08-27T10:21:01.022-07:00<div class='posterous_autopost'> <div style='padding: 5px 5px 10px 5px; margin-top: 5px; border: 1px solid #ddd; background-color: #fff;line-height: 16px;'> <div style="float: left; margin-right: 5px; overflow: visible;"><a href='http://posterous.com/getfile/files.posterous.com/nocx/B6LZF7IbarJ3MhWIZSyqNFIYZoC7KYeLYYR3oTFv9dZN5EhzLImiICvRPbXN/VIDEO0003.3gp' style='color: #bc7134;'><img src='http://posterous.com/images/filetypes/unknown.png' style='border: none;'/></a></div> <div style="font-size: 10px; color: #424037;line-height: 16px;">Download now or <a href="http://nocx.posterous.com/boot-time-video-with-ssd" style="color: #bc7134">watch on posterous</a></div> <b><a href='http://posterous.com/getfile/files.posterous.com/nocx/B6LZF7IbarJ3MhWIZSyqNFIYZoC7KYeLYYR3oTFv9dZN5EhzLImiICvRPbXN/VIDEO0003.3gp' style='color: #bc7134;'>VIDEO0003.3gp</a></b> <span style="font-size: 10px; color: #424037;">(1934 KB)</span> <br style="clear: both;"/></div> <p><br />11-12 seconds. Intel X 25 M. 2nd generation.<p /><p /></p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/boot-time-video-with-ssd">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2923721162919003703?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-4058143768342007072010-08-25T20:31:00.001-07:002010-08-25T20:31:16.354-07:00<div class='posterous_autopost'>Churning slow and even circles in the dark. <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/night-ride-coming-up">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-405814376834200707?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-50317536727025394112010-08-25T18:48:00.001-07:002010-08-25T18:48:54.624-07:00<div class='posterous_autopost'><div>&quot;commonly encountered shortcomings in fundamental aspects of experimental design mainly during biomarker discovery must be addressed in order to provide robust data. In this Perspective, we assert that successful studies generally use suitable statistical approaches for biomarker definition and confirm results in independent test sets; in addition, we describe a brief set of practical and feasible recommendations that we have developed for investigators to properly identify and qualify proteomic biomarkers, which could also be used as reporting requirements.&quot;</div><p /><a href="http://stm.sciencemag.org/content/2/46/46ps42.short?etoc">http://stm.sciencemag.org/content/2/46/46ps42.short?etoc</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/recommendations-for-biomarker-identification">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5031753672702539411?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-4712651801434772362010-08-24T12:43:00.001-07:002010-08-24T12:43:48.581-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/5sIUuwT7Ns0k2pLk6N8C7gikNbfhQUw2mJi2dADrDGozLyq8fsWURUdbLqn3/shot_1282678681865.jpg'><img src="http://posterous.com/getfile/files.posterous.com/nocx/TSVVXRPEv9uBLaOVsZojhQKRDit08g8PajYV5AbzmO1sbmSB1Y2wPnd6pYuo/shot_1282678681865.jpg.scaled.500.jpg" width="500" height="500"/></a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/pm-coffee-pic">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-471265180143477236?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-17318585060702287862010-08-23T18:19:00.001-07:002010-08-23T18:19:20.525-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/z3tttEcumaWWFySoYX4FhNtqD9WctxHFFZXqXAj8Vx3YbV6u87L8vWDvNmuP/shot_1282602152723.jpg'><img src="http://posterous.com/getfile/files.posterous.com/nocx/V2uxIpGmqdeGnWXh1vUdFp5KoBAnnlMaRfj09iIH4OWOvMQxVVFTzOBl8SYj/shot_1282602152723.jpg.scaled.500.jpg" width="500" height="500"/></a> <p><p />Sent from my HTC<p /></p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/retro-camera-pic-rock-garden">nocx</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1731858506070228786?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-49041903281950969492010-08-17T16:51:00.001-07:002010-08-17T16:51:21.654-07:00<div class='posterous_autopost'><div>Using methylation sensitive SNP chip methods, </div><p /><div>&quot;<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0011357">Our large-scale genome DNA methylation profiling</a> reveals that the</div> <div>prefrontal, occipital, and temporal regions of the cerebral cortex compared to cerebellum have markedly different DNA</div><div>methylation signatures, with the cerebral cortex being hypermethylated and cerebellum being hypomethylated. Such</div> <div>differences were observed in distinct genomic regions, including genes involved in CNS function. The MSNP data were</div><div>validated for a subset of these genes, by performing bisulfite cloning and sequencing and confirming that prefrontal,</div> <div>occipital, and temporal cortices are significantly more methylated as compared to the cerebellum.&quot;</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/genome-wide-divergence-of-dna-methylation-mar">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4904190328195096949?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-286198717400233892010-08-15T15:50:00.001-07:002010-08-15T15:50:10.167-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/M0blKLM5yWjJoyPeO4X8xxBKjAoDKlfgDi1IYnDeI4r89L07r49knhfRwx6s/android_banshee_Screenshot.png.scaled.1000.jpg'><img src="http://posterous.com/getfile/files.posterous.com/nocx/AUd8Pgqfauj5IXOuz1CtI8QvAfvn5j3NQv4egD9p8zbMCvafK9LbjEfVc4V2/android_banshee_Screenshot.png.scaled.500.jpg" width="500" height="303"/></a> <p></p><div>Via Youtube&#39;s rohanr2 -- </div><p /><p /><object height="300" width="500"><param name="movie" value="http://www.youtube.com/v/PJMdTYek8Cs&hl=en&fs=1&hd=1" /></param><param name="wmode" value="window" /><param name="allowFullScreen" value="true" /></param><param name="allowscriptaccess" value="always" /></param><embed src="http://www.youtube.com/v/PJMdTYek8Cs&hl=en&fs=1&hd=1" allowfullscreen="true" type="application/x-shockwave-flash" allowscriptaccess="always" wmode="window" height="300" width="500"></embed></object> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/syncing-music-android-htc-desire-with-ubuntu">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-28619871740023389?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-50615612547062788322010-08-12T19:07:00.001-07:002010-08-12T19:07:41.199-07:00<div class='posterous_autopost'><div>Here&#39;s what worked for me:</div><p />1. Get the IMEI code from your new phone after you charge it all the way.  <span style="font-family: courier new, monospace;">You get this by entering *#06# into the dialer.</span><div> <br /><div><div>2. Get the SIM card unlock code for the HTC Desire from a reputable internet seller. They will need your IMEI. </div> <div>I used CellUnlock.net and they were very good.</div><p /> <div>3. Put your Rogers SIM card in the Telus Desire, put in the battery and restart your phone.</div><p /><div>4. The Desire will prompt you for the 8 digit SIM unlock code when you try to use it. Enter it.</div><div>Now half of it should be working - you should have talk and text.  The top right will show how many</div> <div>bars of signal you have. </div><p /><div>5. You will still need to get your data access point connected --</div> <p /><div>6. On the Desire, make sure Network Mode is set for WCDMA only, or GSM/WCDMA (which is the default).  </div> <div>You will not get data on GSM only. [Go figure.]</div><p /> <div>7. Enter your new access point name (APN) and settings:</div><div><dl style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> <dt style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> Name</dt><dd style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.5em; margin-left: 1em; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> Rogers</dd><dt style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> APN</dt><dd style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.5em; margin-left: 1em; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> <a href="http://internet.com">internet.com</a></dd><dt style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> Username</dt><dd style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.5em; margin-left: 1em; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> wapuser1</dd><dt style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> Password</dt><dd style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.5em; margin-left: 1em; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> wap</dd><dt style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> MCC</dt><dd style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.5em; margin-left: 1em; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> 302 (should already be filled in)</dd><dt style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent;"> MNC</dt><dd style="margin-top: 0px; margin-right: 0px; margin-bottom: 0.5em; margin-left: 1em; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> either 720 or 72 depending on your SIM card (should already be filled in)</dd></dl><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 1.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> Leave all other settings blank.   </p><p style="margin-top: 0px; margin-right: 0px; margin-bottom: 1.7em; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; vertical-align: baseline; background-color: transparent; line-height: 1.5em; text-align: justify;"> <a href="http://thekidd.ca/blog/2009/05/rogers-apn-configuration-for-android-phones/">http://thekidd.ca/blog/2009/05/rogers-apn-configuration-for-android-phones/</a></p> </div><div>8. Save your new access point name.</div><p /> <div>9. Try playing with the browser, search or Market.  You should see the up and down arrows in the top right corner and now have data too.</div> <p /><p /><p /><p /><p /><div> </div></div></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/unlock-telus-htc-desire-using-rogers-sim-card">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5061561254706278832?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com1tag:blogger.com,1999:blog-4303195686193514194.post-84755988927787542102010-08-11T07:26:00.001-07:002010-08-11T07:26:04.249-07:00<div class='posterous_autopost'><div>5 minute podcast here: <div id="quicktime_embed-yehtqDfFGs"> <embed href="http://www.audiodizer.com/technologyreview/biomedicine/25954.mp3" scale="aspect" src="http://posterous.com/mp3player/mp3_shell.png" autoplay="false" type="video/quicktime" height="100" target="myself" controller="false" width="500"> </embed> </div> <div id="flash_embed-yehtqDfFGs"> <embed src="/mp3player/posterousplayer.swf" height="100" flashvars="file=http%3A%2F%2Fwww.audiodizer.com%2Ftechnologyreview%2Fbiomedicine%2F25954.mp3" width="500" bgcolor="#FFFFFF" /> </div> <script language="javascript" type="text/javascript"> var agent=navigator.userAgent.toLowerCase(); var is_iphone = (agent.indexOf('mobile')!=-1) && ((agent.indexOf('iphone')!=-1) || (agent.indexOf('ipod')!=-1)); if (is_iphone) { $('quicktime_embed-yehtqDfFGs').show(); $('flash_embed-yehtqDfFGs').hide(); } else { $('flash_embed-yehtqDfFGs').show(); $('quicktime_embed-yehtqDfFGs').hide(); } </script></div><p /><div><a href="http://www.audiodizer.com/technologyreview/biomedicine/25954.mp3"></a><div> &quot;The design principles for the proposed</div><div>system included (1) the ability to facilitate nearly instan-</div><div>taneous, time-of-service queries of a patient’s entire med-</div><div>ical record, on the basis of a clinician’s clinical inference</div> <div>(eg, “I wonder if condition X is mentioned in this pa-</div><div>tient’s record”); (2) the ability to store complex, struc-</div><div>tured queries and activate these automatically on the</div><div>basis of clinical service schedule or care unit census; (3)</div> <div>the ability to rapidly filter a patient’s entire EMR data set</div><div>to a topic-specified or situation-specified dossier (subset);</div><div>and (4) the ability to transmit the output of search either</div><div>to readable forms (Web browser) or other software (ma-</div> <div>chine-to-machine integration).</div><div>The result of these efforts is a system dubbed QPID</div><div>(Queriable Patient Inference Dossier), now in use daily</div><div>in our department.&quot;</div><p /><div> Zallis and Harris, J Am Coll Radiol 2010</div><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/20678732">Abstract and reference here.</a></div><p /><p /></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/advanced-search-of-the-electronic-medical-rec">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8475598892778754210?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-58652172895930543312010-08-10T15:30:00.001-07:002010-08-10T15:30:08.482-07:00<div class='posterous_autopost'>Results from the Duman lab.  Will be interesting if replicated.<p /><div><span style="font-family: arial, helvetica, sans-serif; line-height: 18px;">&quot;Peripheral BDNF administration increased mobility in the FST, attenuated the effects of CUS on sucrose consumption, decreased latency in the NIH test, and increased time spent in the open arms of an EPM. Moreover, adult hippocampal neurogenesis was increased after chronic, peripheral BDNF administration. We also found that BDNF levels as well as expression of pCREB and pERK were elevated in the hippocampus of adult mice receiving peripheral BDNF. &quot;</span><br /> <p /><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/20686454">http://www.ncbi.nlm.nih.gov/pubmed/20686454</a></div></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/peripheral-bdnf-produces-antidepressant-like">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5865217289593054331?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-76819309357061797362010-08-10T13:29:00.001-07:002010-08-10T13:29:58.426-07:00<div class='posterous_autopost'><p>Nicotinic receptor subunit SNP associated with smoking, COPD, lung cancer.  </p> <p><a href="http://feeds.plos.org/~r/plosgenetics/NewArticles/~3/YM3AvgwCjwA/info%3Adoi%2F10.1371%2Fjournal.pgen.1001053">http://feeds.plos.org/~r/plosgenetics/NewArticles/~3/YM3AvgwCjwA/info%3Adoi%2F10.1371%2Fjournal.pgen.1001053</a></p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/multiple-independent-loci-at-chromosome-15q25">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7681930935706179736?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-22665087914412216662010-08-08T21:43:00.001-07:002010-08-08T21:43:57.456-07:00<div class='posterous_autopost'><span style="font-family: arial, helvetica, sans-serif; font-size: 12px; line-height: 18px;"><h1 class="title" style="font-size: 1.3333em; line-height: 1.125em; margin-right: 0px; margin-left: 0px;"> <span style="font-weight: normal;">Transcriptional control of the glucocorticoid receptor: CpG islands, epigenetics and more.</span></h1><p /><div><span style="font-weight: normal;" /><h1 class="title" style="line-height: 1.125em; margin-right: 0px; margin-left: 0px;"><span style="font-weight: normal;"><span style="font-size: small;">Biochem Pharmacol</span></span></h1> </div></span><div><a href="http://www.ncbi.nlm.nih.gov/pubmed/20599772">Turner et al.</a></div><div>&quot;the multiple first exons represent only a first layer of complexity orchestrated probably by tissue-specific transcription factors. Modulation of alternative first exon activity by epigenetic methylation of their promoters represents a second layer of complexity at least partially controlled by perinatal programming. The alternative promoter usage also appears to affect the 3&#39; splicing generating the different GR coding variants, GRalpha, GRbeta, and GR-P.&quot;</div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/transcriptional-control-of-the-glucocorticoid">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2266508791441221666?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-2916327601925111962010-08-05T14:52:00.001-07:002010-08-05T14:52:35.617-07:00<div class='posterous_autopost'><p align="JUSTIFY" style="margin-left: 0.25in; margin-bottom: 0in; line-height: 100%;">Dolinoy et al. 2007:</p><p align="JUSTIFY" style="margin-left: 0.25in; margin-bottom: 0in; line-height: 100%;"> Polymorphic CpG sites can be considered metastable epialleles that are variably expressed and are thought to be particularly vulnerable to environmental influences.</p><p align="JUSTIFY" style="margin-left: 0.25in; margin-bottom: 0in; line-height: 100%;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/17413847">http://www.ncbi.nlm.nih.gov/pubmed/17413847</a></p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/polymorphic-cpg-sites-can-be-considered-metas">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-291632760192511196?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-749134408107955542010-08-03T08:40:00.001-07:002010-08-03T08:40:09.735-07:00<div class='posterous_autopost'><span style="font-family: Verdana, arial, Helvetica, sans-serif; font-size: 14px;"><h2 style="font-weight: normal;"><span style="font-size: small;">Functional analysis of multiple genomic signatures demonstrates that classification algorithms choose phenotype-related genes</span></h2> <div>by Shi and colleagues:</div><p /><div><span style="font-size: 13px;">&quot;A comprehensive analysis of the genes of these signatures and their nonredundant unions using ontology enrichment, biological network building and interactome connectivity analyses demonstrated the link between gene signatures and the biological basis of their predictive power.&quot;</span></div> <p /><div><a href="http://www.nature.com/tpj/journal/v10/n4/abs/tpj201035a.html">http://www.nature.com/tpj/journal/v10/n4/abs/tpj201035a.html</a></div><p /></span> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/shi-et-al-the-pharmacogenomics-journal-genomi">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-74913440810795554?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-745503108722991732010-08-02T18:54:00.001-07:002010-08-02T18:54:03.933-07:00<div class='posterous_autopost'><div style="font-family: verdana, arial, helvetica, sans-serif;"><div><div style="font-family: verdana, arial, helvetica, sans-serif;">This was an fMRI study in 110 healthy subjects:</div></div> <p /></div>&quot;healthy carriers of the <i>CACNA1C</i> risk variant exhibit apronounced reduction of bilateral hippocampal activation duringepisodic memory recall and diminished functional coupling betweenleft and right hippocampal regions. Furthermore, risk allelecarriers exhibit activation deficits of the subgenual anteriorcingulate cortex, a region repeatedly associated with affectivedisorders and the mediation of adaptive stress-related responses.&quot;<p /><div><span style="font-family: verdana, arial, helvetica, sans-serif;">This SNP was originally associated with Bipolar Disorder, by GWAS.</span></div> <p /><div><a href="http://archpsyc.ama-assn.org/cgi/content/abstract/67/8/803?etoc">http://archpsyc.ama-assn.org/cgi/content/abstract/67/8/803?etoc</a></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/arch-gen-psychiatry-cacna1c-allele-associated">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-74550310872299173?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-20509813705109952352010-07-29T06:17:00.001-07:002010-07-29T06:17:54.884-07:00<div class='posterous_autopost'><div><span style="font-family: arial, helvetica, sans-serif; font-size: 12px; line-height: 18px;" /><h1 class="title" style="font-size: 1.3333em; line-height: 1.125em; margin-right: 0px; margin-left: 0px;"> <span style="font-weight: normal;"><br /></span></h1><h1 class="title" style="font-size: 1.3333em; line-height: 1.125em; margin-right: 0px; margin-left: 0px;"> <span style="font-weight: normal;">Evaluation of a generalizable approach to clinical information retrieval using the automated retrieval console (ARC).</span></h1></div><div>D&#39;Avolio et al. 2010</div> <p /><div>&quot;The ARC  . . . is available as open-source software at <a href="http://research.maveric.org/mig/arc.html">http://research.maveric.org/mig/arc.html</a> &quot;</div><p /><a href="http://www.ncbi.nlm.nih.gov/pubmed/20595303">http://www.ncbi.nlm.nih.gov/pubmed/20595303</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/davolio-et-al-jamia-on-nlp-for-clinical-infor">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2050981370510995235?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-80943822088518837262010-07-28T18:53:00.001-07:002010-07-28T18:53:54.368-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/tBY2HmY5XUQg3ORPOgGHYaNxXismJzG7esPc3fGTD0JH5Uc4mPg3wjMfAYxV/VNC.png'><img src="http://posterous.com/getfile/files.posterous.com/nocx/ZeOeFQUTpvFEZwUfA6An0LqxKX0JVsIGu8jLI79aCw7HUjlTtLCDsrSr85Uj/VNC.png.scaled.500.jpg" width="500" height="258"/></a> <p>My first VM. Wahoo!</p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/just-launched-httpwwwtightvnccom-for-ngs-ht-s">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8094382208851883726?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-14390092476081544822010-07-25T15:18:00.001-07:002010-07-25T15:18:45.992-07:00<div class='posterous_autopost'><p><a href="http://www.nature.com/nrg/journal/v11/n8/full/nrg2832.html">http://www.nature.com/nrg/journal/v11/n8/full/nrg2832.html</a></p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/nat-rev-genet-transposons-are-a-major-source">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1439009247608154482?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-33335645884606687742010-06-28T22:20:00.001-07:002010-06-28T22:20:36.722-07:00<div class='posterous_autopost'><span style="font-family: arial, helvetica, sans-serif; font-size: 12px; line-height: 18px;">&quot;These data demonstrate consistent tissue specific methylation for certain CpG islands, with clear differences between white and grey matter of the brain.&quot;</span><p /><div><span style="font-size: 12px; line-height: 18px;"><a href="http://www.ncbi.nlm.nih.gov/pubmed/20505344">http://www.ncbi.nlm.nih.gov/pubmed/20505344</a></span></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/tissue-specific-dna-methylation-of-cpg-island">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3333564588460668774?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-86773751835985256452010-06-28T20:35:00.001-07:002010-06-28T20:35:13.029-07:00<div class='posterous_autopost'><div><span style="font-family: arial, helvetica, sans-serif; font-size: 12px; line-height: 18px;" /><h1 class="title" style="line-height: 1.125em; margin-right: 0px; margin-left: 0px;"> <span style="font-size: small;"><span style="font-weight: normal;">NO Interaction Between Childhood Adversity, Brain-Derived Neurotrophic Factor val/met and Serotonin Transporter Promoter Polymorphism on Depression: The TRAILS Study</span></span></h1> </div><p /><a href="http://www.ncbi.nlm.nih.gov/pubmed/20553751">http://www.ncbi.nlm.nih.gov/pubmed/20553751</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/childhood-adversity-brain-derived-neurotrophi">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8677375183598525645?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-65952613114567089092010-06-25T17:12:00.001-07:002010-06-25T17:12:12.496-07:00<div class='posterous_autopost'><object height="417" width="500"><param name="movie" value="http://www.youtube.com/v/Q9tT_ayevHQ&hl=en&fs=1" /></param><param name="wmode" value="window" /><param name="allowFullScreen" value="true" /></param><param name="allowscriptaccess" value="always" /></param><embed src="http://www.youtube.com/v/Q9tT_ayevHQ&hl=en&fs=1" allowfullscreen="true" type="application/x-shockwave-flash" allowscriptaccess="always" wmode="window" height="417" width="500"></embed></object> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/jaco-pastorius-portrait-of-tracy-236-with-scr">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6595261311456708909?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-4822844745550620612010-06-25T07:09:00.001-07:002010-06-25T07:09:41.466-07:00<div class='posterous_autopost'>&quot;Plasma samples from 245 depressed patients, 229 schizophrenic patients and 254 controls were submitted to multi analyte profiling allowing the evaluation of up to 79 proteins, including a series of cytokines, chemokines and neurotrophins previously suggested to be involved in the pathophysiology of depression and schizophrenia.&quot; <p /><a href="http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009166">http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009166</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/plos-one-plasma-protein-biomarkers-for-depres">nocx-ville</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-482284474555062061?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-66422193302224603042010-06-23T17:36:00.001-07:002010-06-23T17:36:17.441-07:00<div class='posterous_autopost'><div><span style="font-family: Arial, Helvetica, sans-serif; font-size: 12px;"><span style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; font-size: 12px; background-color: transparent;">neuGRID is a user-friendly grid-based e-Infrastructure which enables the neuroscience community </span></span><span style="font-family: Arial, Helvetica, sans-serif; font-size: 12px;">to collect and archive large amounts of imaging data and to access resources for computationally intensive data analyses.</span></div> <p /><object height="417" width="500"><param name="movie" value="http://www.youtube.com/v/L5tD_u52JvA&hl=en&fs=1" /></param><param name="wmode" value="window" /><param name="allowFullScreen" value="true" /></param><param name="allowscriptaccess" value="always" /></param><embed src="http://www.youtube.com/v/L5tD_u52JvA&hl=en&fs=1" allowfullscreen="true" type="application/x-shockwave-flash" allowscriptaccess="always" wmode="window" height="417" width="500"></embed></object> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/learning-about-neugrid">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6642219330222460304?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-81080227187640902912010-06-23T07:19:00.001-07:002010-06-23T07:19:02.110-07:00<div class='posterous_autopost'>High-power lithium batteries from functionalized carbon-nanotube electrodes<p /><a href="http://www.nature.com/nnano/journal/vaop/ncurrent/abs/nnano.2010.116.html">http://www.nature.com/nnano/journal/vaop/ncurrent/abs/nnano.2010.116.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/nat-nanotech-carbon-nanotube-eletrodes">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8108022718764090291?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-15377330430994129792010-06-20T08:23:00.001-07:002010-06-20T08:23:58.903-07:00<div class='posterous_autopost'><div><span style="font-family: Verdana, Arial, Helvetica, sans-serif; line-height: 14px;">&quot;Using a global, comparative CpG methylation profiling approach we identified many novel examples of active DNA demethylation and characterised accompanying transcriptional and epigenetic events at these sites during monocytic differentiation. We show that active DNA demethylation is not restricted to proximal promoters and that the time-course of demethylation varies for individual CpGs.&quot;</span></div> <p /><a href="http://genomebiology.com/2010/11/6/R63/abstract">http://genomebiology.com/2010/11/6/R63/abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/active-dna-demethylation-in-human-postmitotic">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1537733043099412979?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-13489393235801829592010-06-19T07:02:00.001-07:002010-06-19T07:02:13.163-07:00<div class='posterous_autopost'><a href="http://www.nature.com/hdy/journal/v105/n1/abs/hdy201025a.html">http://www.nature.com/hdy/journal/v105/n1/abs/hdy201025a.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/epigenomic-plasticity-within-populations-its">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1348939323580182959?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-38368130828789550312010-06-19T07:00:00.001-07:002010-06-19T07:00:33.726-07:00<div class='posterous_autopost'><a href="http://www.nature.com/hdy/journal/v105/n1/full/hdy201054a.html">http://www.nature.com/hdy/journal/v105/n1/full/hdy201054a.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/heredity-review-epigenetics-and-gene-expressi">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3836813082878955031?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-40397416455440135432010-06-11T20:39:00.001-07:002010-06-11T20:39:27.202-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/DDyvopbbpwqAplriaBFGDllJsFzGwjdlnboflttffhzypeaBkznyrtGGpmdu/media_httpitaliaanser_JqgEb.jpg.scaled1000.jpg'><img src="http://posterous.com/getfile/files.posterous.com/nocx/DDyvopbbpwqAplriaBFGDllJsFzGwjdlnboflttffhzypeaBkznyrtGGpmdu/media_httpitaliaanser_JqgEb.jpg.scaled500.jpg" width="500" height="370"/></a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/colnagos-1971-merckx-design">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4039741645544013543?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-36537721930227173932010-06-10T13:07:00.001-07:002010-06-10T18:12:17.515-07:00<div class="posterous_autopost"><div style="margin-bottom: 0in;">Canada, Check Your Privacy Settings</div><div style="margin-bottom: 0in;">Ann Cavoukian IPC</div><div style="margin-bottom: 0in;">Ronald Deibert</div><div style="margin-bottom: 0in;">Mod Jesse Hirsh</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Ann Cavoukian</div><div style="margin-bottom: 0in;">Need to get rid of zero sum game notion: functionality verus privacy is a bad news game.</div><div style="margin-bottom: 0in;">Privacy relates to personally identifiable identifiers (PII) name address, social insrance number</div><div style="margin-bottom: 0in;">Open access – re public information, non-PII.</div><div style="margin-bottom: 0in;">Fundamental essence is that user controls PII. User in control. For non-PII, there should be little if any control.</div><div style="margin-bottom: 0in;">Privacy=Freedom</div><div style="margin-bottom: 0in;">State censorship the antithesis of privacy.</div><div style="margin-bottom: 0in;">Human condition thrives on freedom.</div><div style="margin-bottom: 0in;">Informational Self-Determination. Individual determines the fate of their information. Germany a world leader. </div><div style="margin-bottom: 0in;">Privacy does not equal security.</div><div style="margin-bottom: 0in;">Can have strong security without privacy.</div><div style="margin-bottom: 0in;">You must have both.</div><div style="margin-bottom: 0in;">Privacy is the first to go out the window e.g. 9/11.</div><div style="margin-bottom: 0in;">We need to change the paradigm.</div><div style="margin-bottom: 0in;">Need to prevent harms. Must prevent data breaches.</div><div style="margin-bottom: 0in;"><a href="http://www.privacybydesign.ca/">www.privacybydesign.ca</a></div><div style="margin-bottom: 0in;">Change paradigm from zero-sum to positive sum, win-win.</div><div style="margin-bottom: 0in;">Privacy must be embedded into the design of a system.</div><div style="margin-bottom: 0in;">Add-on does not work as well as intrinsic methods.</div><div style="margin-bottom: 0in;">End-to-end lifecycle protection – data destruction.</div><div style="margin-bottom: 0in;">Respect for individuals.</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Deibert</div><div style="margin-bottom: 0in;"></div><div style="margin-bottom: 0in;">Tracking Ghostnet</div><div style="margin-bottom: 0in;">Shadows in the Cloud</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Victims of cyber espionage dozens of governments media, UN, Deloitte, Associated Press</div><div style="margin-bottom: 0in;">Advanced social engineering using email – Well written, real details malicious attachments /payload</div><div style="margin-bottom: 0in;">One of the computers compromised was an antivirus service in Taiwan. </div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Indian govt compromised – 700 documents recovered that had been stolen. e.g. Armed Forces. Defense contract information. </div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Ghostnet and Shadows a disturbing arms race in cyberspace.</div><div style="margin-bottom: 0in;">Disturbing geopolitical competition. Domain that is carved up, colonized and militarized.</div><div style="margin-bottom: 0in;">Needed:</div><br /><ol><li><br /><br /><div style="margin-bottom: 0in;">Global Treaty of Cyberspace needed. Because the web is a valuable commons.</div></li><li><br /><br /><div style="margin-bottom: 0in;">Global Monitoring and Early Warning System International Information sharing Mechanisms. </div></li><li><br /><br /><div style="margin-bottom: 0in;">Support Cyberspace Openness</div></li></ol><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Discussion</div><div style="margin-bottom: 0in;">European Privacy leadership and FTC and FCC leaders are embracing privacy by design.</div><div style="margin-bottom: 0in;">Younger generations value privacy as much as older. </div><div style="margin-bottom: 0in;">R. Deibert discusses ethical and legal framework of University and Canada. Citizenlab workers risk being declared spies by other countries. </div><div style="margin-bottom: 0in;">Anything you put out, be mindful -- it could end up anywhere, without control.</div><div style="margin-bottom: 0in;">Cloud computing/social network data does exist on real servers which may exist in jurisdictions where privacy legislation is different than here.</div><div style="margin-bottom: 0in;">Many parts of the world there is no oversight, e.g. anonymous web surfing service hands over data to a research lab's request.</div><div style="margin-bottom: 0in;">Smartgrid – will have privacy-by-design embedded in its development.</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">R. Deibert laments metamorphsois of word hacking. Hacking was originally about tinkering, not lawlessness. #hacktivism Now we have a litigious culture of fear. e.g. Don't open this digital lock, have a lawyer with you when you read your EULA.</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Question re emerging models of Electronic Health Records. Cavoukian Answer – Ontario is tied for last, at the bottom, with Nunavut, for EHR use. Cavoukian wants EHRs with privacy, the positive sum game. Says this as a patient who has had procedures. Cavoukian contacted Telus re HealthSpace, wanted to test it.</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Q: The power government and capital have in benefiting from a lack of privacy.</div><div style="margin-bottom: 0in;">A. Cavoukian and others influenced Google to make default gmail account secure.</div><div style="margin-bottom: 0in;">Biometric encryption – there is no representation of your actual biometric – in Netherlands and Israel.</div><div style="margin-bottom: 0in;"><br /></div><div style="margin-bottom: 0in;">Cavoukian to @cavoukian: “Have the guts to put your own name on it . . . Appalling.”</div><div style="font-size: 10px;"><a href="http://posterous.com/">Posted via email</a> from <a href="http://nocx.posterous.com/canada-check-your-privacy-settings-notes-ncwk">the nocx files</a> </div></div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3653772193022717393?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-55503386611613611542010-06-10T12:42:00.001-07:002010-06-10T12:42:17.554-07:00<div class='posterous_autopost'> <p style="margin-bottom: 0in;">The Future of the Web and the World</p> <p style="margin-bottom: 0in;">Gerri Sinclair</p> <p style="margin-bottom: 0in;">Lucy Bernholz</p> <p style="margin-bottom: 0in;">John Thackara</p> <p style="margin-bottom: 0in;">Mod Jesse Brown</p> <p style="margin-bottom: 0in;"><br /> </p> <p style="margin-bottom: 0in;">Gerri Sinclair on the Future, trends.</p> <p style="margin-bottom: 0in;">Moore&#39;s Law + Network effect &gt; change amplified</p><p style="margin-bottom: 0in;">Trends:</p><ol><li><p style="margin-bottom: 0in;">Recombinant innovation – knowledge recombined, mashed up</p> </li><li><p style="margin-bottom: 0in;">Beyond eLearning – lectures and slides uploaded, Open University. New models of collaboration – wikis. e.g. <a href="http://www.khanacademy.org/">www.khanacademy.org</a></p> </li><li><p style="margin-bottom: 0in;">Demise of the professional - growth of the professional amateur</p> </li><li><p style="margin-bottom: 0in;">Openness ubiquitious - Open Source; Open Data</p> </li><li><p style="margin-bottom: 0in;">Mathematician as rockstar breakthrough in mathematics, data deluge; consumer as data.</p> </li><li><p style="margin-bottom: 0in;">Transparency vs. privacy. Loss of privacy, but new accountability. Wikileaks- US Army. Classified data leaked in searchable format.</p> </li><li><p style="margin-bottom: 0in;">Threats/ benefits of the cloud. Gmail, Facebook, </p> </li><li><p style="margin-bottom: 0in;">Big Brother is watching you. Japan/Korea. Wireless sensors+robotics</p> </li><li><p style="margin-bottom: 0in;">Evolution of the Web - 3d immersification</p> </li><li><p style="margin-bottom: 0in;">Gameification of media – Education, Health, Fitness. Digital media becoming fundamental currency of eduction. Game engines, tourism, health, environment.</p> </li><li><p style="margin-bottom: 0in;">Reality continuum – hybrid reality (SMS/homework); AR; continuous partial attention; Book Exodus to the Virtual World</p> </li><li><p style="margin-bottom: 0in;">Online Demographics. Silent Gen. /Boomers/Gen X/ Gen Y/ Gen V (Avatars- relationships will be primarily digital). Penguin Club. Cartoon Doll Emporium.</p> </li><li><p style="margin-bottom: 0in;">Multiple identities – Who am I?</p> </li></ol> <p style="margin-bottom: 0in;"><br /> </p> <p style="margin-bottom: 0in;">Lucy Bernholz:</p> <p style="margin-bottom: 0in;">Technology having effects on how people do good.</p> <p style="margin-bottom: 0in;">Most ideas from her talk found in paper – Disrupting Philanthropy.</p> <p style="margin-bottom: 0in;">Data will be platform for change.</p> <p style="margin-bottom: 0in;">e.g. Action supporting Haiti earthquake relief by cell phone or computer. #crisiscamp</p> <p style="margin-bottom: 0in;">&gt; went global – Ottawa London Bogata; no institutional support. Peoplefinder app for tagged photos of missing relatives. Creole &gt; English tweet translator.</p> <p style="margin-bottom: 0in;">“Data is anything that can be digitized.”</p> <p style="margin-bottom: 0in;">Grandma biggest fan of iPad.</p> <p style="margin-bottom: 0in;">Phone gives proximity to data and expertise, gives value to organizations.</p> <p style="margin-bottom: 0in;">Fundamental upset to the role of the institution.</p> <p style="margin-bottom: 0in;">Governance is a problem for groups like Crisis Commons. Not an official nonprofit.</p> <p style="margin-bottom: 0in;">Laws will need to change.</p> <p style="margin-bottom: 0in;">A revolution in where social goods come from and how they change.</p> <p style="margin-bottom: 0in;">New roles for public, private, independent sector. </p> <p style="margin-bottom: 0in;">“We have a very new meaning of place.”</p> <p style="margin-bottom: 0in;">New defintions of scale – can be small and global at the same time.</p> <p style="margin-bottom: 0in;"><br /> </p> <p style="margin-bottom: 0in;">John Thackara:</p> <p style="margin-bottom: 0in;">I don&#39;t want to be led by technology. It&#39;s a means for us to do things.</p> <p style="margin-bottom: 0in;">What needs to be fixed and how do we do it?</p> <p style="margin-bottom: 0in;">Doomsday economy: Actions described as positive for economy, direct consequences for </p> <p style="margin-bottom: 0in;">biosphere. Pretty serious.</p> <p style="margin-bottom: 0in;">Alternative solidarity economy: In some places, people are reorganizing their daily lives for reduced impact on environment.</p> <p style="margin-bottom: 0in;">The hours spent looking after others are ways of creating social good, just not yet described yet as economic activity. A very European point of view. More people have access to mobile phones than clean water in the world. Depraved: replacing care by people with care by machines. </p> <p style="margin-bottom: 0in;">You can&#39;t grow food with an iPhone.</p> <p style="margin-bottom: 0in;">You shouldn&#39;t look after an elderly person with an iPhone.</p> <p style="margin-bottom: 0in;"></p><p style="margin-bottom: 0in;">Brown/Bernholz interlude: OLPC &gt; tablets, netbooks, drove price of tech down.</p> <p style="margin-bottom: 0in;"><a href="http://myc4.org">myc4.org</a> &gt;&gt; micropayments to Africa – you control over investment vs. loan, set your own interest rate.</p> <p style="margin-bottom: 0in;"><br /> </p> <p style="margin-bottom: 0in;">Panel – a sharing economy will be a huge part of sustainability</p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/the-future-of-the-web-and-the-world-notes-ncw">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5550338661161361154?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-61909031758015783492010-06-09T05:21:00.001-07:002010-06-09T05:21:41.629-07:00<div class='posterous_autopost'>A problem with whole genome duplication?<p /><a href="http://www.biomedcentral.com/1471-2164/11/313/abstract">http://www.biomedcentral.com/1471-2164/11/313/abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/the-collapse-of-gene-complement-following-who">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6190903175801578349?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-83196522291343339912010-06-09T05:10:00.001-07:002010-06-09T05:10:11.166-07:00<div class='posterous_autopost'>Hackenberg et al. show that their clustering method, CpGcluster, is better at detecting short, often differentially methylated CpG islands<br />than sliding-window methods.<br />&quot;The major difference in the prediction was found for short islands (CpG islets), often exclusively predicted by CpGcluster.&quot;<p /><a href="http://www.biomedcentral.com/1471-2164/11/327/abstract">http://www.biomedcentral.com/1471-2164/11/327/abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/prediction-of-cpg-island-function-cpg-cluster">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-8319652229134333991?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-12512774943469421232010-06-07T20:09:00.001-07:002010-06-07T20:09:22.565-07:00<div class='posterous_autopost'><div>Big bundle of tools here, many web-based.</div><div>Make sure to read the disclaimer at the top of the page:</div><p /><a href="http://www.geneontology.org/GO.tools.microarray.shtml">http://www.geneontology.org/GO.tools.microarray.shtml</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/learning-about-tools-that-use-gene-ontology-f">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1251277494346942123?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-45543648567120383062010-06-07T12:34:00.001-07:002010-06-07T12:34:43.159-07:00<div class='posterous_autopost'><h1 class="title" style="font-weight: normal;">Hu et al.</h1><h1 class="title" style="font-weight: normal;">SHEsisEpi, a GPU-enhanced genome-wide SNP-SNP interaction scanning algorithm, efficiently reveals the risk of genetic epistasis in bipolar disorder.</h1>Hu and colleagues developed a method for analyzing epistasis in a GWAS of complex traits, and exclude the contamination of marginal effects caused by single-locus association. They analyzed the Wellcome Trust Case Control Consortium&#39;s (WTCCC) bipolar disorder GWAS data.<p /><a href="http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201068a.html">http://www.nature.com/cr/journal/vaop/ncurrent/full/cr201068a.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/cell-research-shesisepi-a-gpu-enhanced-genome">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4554364856712038306?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-20685762374871100112010-05-30T11:48:00.001-07:002010-05-30T11:48:11.497-07:00<div class='posterous_autopost'><h1 class="title">MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.</h1>You can get the paper <a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2705205/?tool=pubmed">here</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/pharmacogenomics-is-mirna-the-future-of-pheno">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2068576237487110011?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-52515285357886136002010-05-27T10:52:00.001-07:002010-05-27T10:52:50.073-07:00<div class='posterous_autopost'><a href="http://www.ncbi.nlm.nih.gov/pubmed/19923361">http://www.ncbi.nlm.nih.gov/pubmed/19923361</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/endurance-training-enhances-bdnf-release-from">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5251528535788613600?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-11648232479268076982010-05-25T04:41:00.001-07:002010-05-25T04:41:52.442-07:00<div class='posterous_autopost'><div><span style="font-family: Verdana, Lucida, Arial, Helvetica, sans-serif; font-size: 10px; color: rgb(51, 51, 51); line-height: 13px;" /><h1 style="margin-top: 10px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; font-weight: normal; font-style: inherit; font-family: Verdana, Lucida, Arial, Helvetica, sans-serif; line-height: 1.33; text-align: left; vertical-align: baseline;"> <span style="font-size: small;">Seltzer et al. </span></h1><h1 style="margin-top: 10px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px; padding-top: 0px; padding-right: 0px; padding-bottom: 0px; padding-left: 0px; border-top-width: 0px; border-right-width: 0px; border-bottom-width: 0px; border-left-width: 0px; border-color: initial; font-weight: normal; font-style: inherit; font-family: Verdana, Lucida, Arial, Helvetica, sans-serif; line-height: 1.33; text-align: left; vertical-align: baseline;"> <span style="font-size: small;">Social vocalizations can release oxytocin in humans, via @CynthiaHenrich</span></h1><p /></div> <p /><a href="http://rspb.royalsocietypublishing.org/content/early/2010/05/06/rspb.2010.0567.short?rss=1">http://rspb.royalsocietypublishing.org/content/early/2010/05/06/rspb.2010.0567.short?rss=1</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/proc-royal-soc-b-oxytocin-stress-mothers-talk">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1164823247926807698?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-38953146495682264302010-05-24T12:03:00.001-07:002010-05-24T12:03:47.192-07:00<div class='posterous_autopost'>Hellman and Chess: Methylation is not independent of SNPs.<p /><a href="http://www.epigeneticsandchromatin.com/content/3/1/11">http://www.epigeneticsandchromatin.com/content/3/1/11</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/extensive-sequence-influenced-dna-methylation">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3895314649568226430?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-43889311987270400792010-05-24T08:25:00.001-07:002010-05-24T08:25:57.489-07:00<div class='posterous_autopost'><div>&#39;Genomic Regions Enrichment of Annotations Tool&#39; </div><div>Mclean et al. </div><div>Nat Biotechnol 28:495–501 2010</div><p /><div>The software completes an analysis showing which genes a transcription factor is likely to influence, and the relevant molecular pathways, across the genome.  It incorporates proximal and distal binding and controls for false positives using a binomial test.</div> <p /><a href="http://www.nature.com/nbt/journal/v28/n5/abs/nbt.1630.html">http://www.nature.com/nbt/journal/v28/n5/abs/nbt.1630.html</a><p /><div><a href="http://great.stanford.edu">GREAT website.</a></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/great-improves-functional-interpretation-of-c">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4388931198727040079?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-78417856420628107402010-05-19T17:50:00.001-07:002010-05-19T17:50:09.699-07:00<div class='posterous_autopost'><div>The &quot;approach automatically extracts potentially linkable clinical features and modifies them in a way that they can no longer be used to link a genomic sequence to a small number of patients, while preserving the associations between genomic sequences and specific sets of clinical features corresponding to GWAS-related diseases.&quot;</div><p /><a href="http://www.pnas.org/content/early/2010/04/05/0911686107.abstract">http://www.pnas.org/content/early/2010/04/05/0911686107.abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/anonymization-of-electronic-medical-records-f-0">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7841785642062810740?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-56524519401195127922010-05-18T18:28:00.001-07:002010-05-18T18:28:42.637-07:00<div class='posterous_autopost'><div>Paper <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000371">here</a>.</div><p /><div>Editorials --</div><p /><a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000370">http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000370</a><p /><div><a href="http://www.nature.com/news/2010/100518/full/news.2010.248.html?s=news_rss#B5">http://www.nature.com/news/2010/100518/full/news.2010.248.html?s=news_rss#B5</a></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/rna-transcripts-from-junk-dna-how-abundant-ar">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5652451940119512792?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-60165855173317129612010-05-17T13:47:00.001-07:002010-05-17T13:47:09.883-07:00<div class='posterous_autopost'><div><span style="font-family: Helvetica Neue; font-size: 14px; line-height: 20px;">&quot;Human Language Technologies: The 11th Annual Conference of the <a href="http://www.naacl.org/" target="_blank" style="text-decoration: none; border-bottom-width: 1px; border-bottom-style: dotted; border-bottom-color: rgb(51, 51, 51); color: black;">North American Chapter</a> of the <a href="http://www.aclweb.org/" target="_blank" style="text-decoration: none; border-bottom-width: 1px; border-bottom-style: solid; border-bottom-color: rgb(17, 123, 172); color: rgb(17, 123, 172);">Association for Computational Linguistics</a> will be held June 1–6, 2010 in downtown Los Angeles &quot;</span></div> <p /><a href="http://naaclhlt2010.isi.edu/papers.html">http://naaclhlt2010.isi.edu/papers.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/papers-for-11th-naacl-north-american-associat">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6016585517331712961?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-30274501761768507902010-05-13T17:03:00.001-07:002010-05-13T17:03:44.600-07:00<div class='posterous_autopost'><a href="http://tedxtokyo.com/blog/renee-byer/">http://tedxtokyo.com/blog/renee-byer/</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/renee-byer-tedx-talk-on-her-photojournalism">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3027450176176850790?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-72510578577666525802010-05-11T19:54:00.001-07:002010-05-11T19:54:32.910-07:00<div class='posterous_autopost'><div>The Locus Reference Genomic (LRG) sequence format &quot;<span style="line-height: 14px;">builds on the successful National Center for Biotechnology Information (NCBI) RefSeqGene project and provides a single-file record containing a uniquely stable reference DNA sequence along with all relevant transcript and protein sequences essential to the description of gene variants.<span style="line-height: normal;">&quot;</span></span></div> <p /> <a href="http://genomemedicine.com/content/2/4/24/abstract">http://genomemedicine.com/content/2/4/24/abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/genome-medicine-locus-reference-genomic-seque">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7251057857766652580?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-17151349500988276942010-05-09T09:56:00.001-07:002010-05-09T09:56:19.122-07:00<div class='posterous_autopost'><span style="font-family: arial, verdana, sans-serif; font-size: 12px;">&quot;We conclude that about 904 miRNAs are expressed in human leukocytes.&quot;</span><p /><div><span style="font-size: 12px;"><a href="http://www.biomedcentral.com/1471-2164/11/288/abstract">http://www.biomedcentral.com/1471-2164/11/288/abstract</a></span></div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/bmc-genomics-analysis-of-microrna-transcripto">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1715134950098827694?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-53377021684313786472010-05-09T09:53:00.001-07:002010-05-09T09:53:02.151-07:00<div class='posterous_autopost'><div><span style="font-family: Verdana, Arial, Helvetica, sans-serif; font-size: 12px;">&quot;This review addresses issues relevant to microRNA function in neurons&quot;</span></div><p /> <a href="http://sciencia.org/stories/694935/MicroRNA_pathways_in_neural_development_and_plasticity.html?utm_source=twitterfeed&amp;utm_medium=twitter&amp;utm_campaign=Feed:+sciencia/rdjI+(Sciencia+-+Neurology)">http://sciencia.org/stories/694935/MicroRNA_pathways_in_neural_development_and_plasticity.html?utm_source=twitterfeed&amp;utm_medium=twitter&amp;utm_campaign=Feed:+sciencia/rdjI+(Sciencia+-+Neurology)</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/current-opinion-neurobiol-microrna-pathways-i">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5337702168431378647?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-13209081001057514352010-05-09T09:46:00.001-07:002010-05-09T09:46:54.514-07:00<div class='posterous_autopost'><div><span style="font-family: Verdana, Geneva, Arial, Helvetica, sans-serif; font-size: 12px; line-height: 18px;">&quot;This approach utilizes linear regression models of non-normalised hybridisation data to define methylation status. Log-transformed signal intensities of unmethylated controls on the microarray are used as a reference. The signal intensities of DNA samples digested with methylation sensitive restriction enzymes and mock digested are then transformed to the likelihood of a locus being methylated using this reference. We tested the ability of MLDA to identify loci differentially methylated as analysed by DMH between cisplatin sensitive and resistant ovarian cancer cell lines. MLDA identified 115 differentially methylated loci and 23 out of 26 of these loci have been independently validated by Methylation Specific PCR and/or bisulphite pyrosequencing.&quot;</span></div> <p /><a href="http://www.biomedcentral.com/1471-2105/9/337">http://www.biomedcentral.com/1471-2105/9/337</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/methylation-linear-discriminant-analysis-mlda">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1320908100105751435?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-71102424037599689232010-05-09T09:44:00.001-07:002010-05-09T09:44:04.126-07:00<div class='posterous_autopost'><div>&quot;<span style="font-family: Times New Roman; font-size: medium;">Cgaln takes less than 13 hours to finish an alignment between the whole genomes of human and mouse in a single run on a conventional desktop computer with a single CPU and 2 GB memory.<span style="font-family: arial; font-size: small;">&quot;</span></span></div> <p /><a href="http://www.biomedcentral.com/1471-2105/11/224">http://www.biomedcentral.com/1471-2105/11/224</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/cgaln-fast-and-space-efficient-whole-genome-a">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7110242403759968923?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-72652959577829900742010-05-07T18:11:00.001-07:002010-05-07T18:11:43.072-07:00<div class='posterous_autopost'> &quot;Observers noted 776 nontiming errorsin medication administration on units that did not use the bar-codeeMAR (an 11.5% error rate) versus 495 such errors on units thatdid use it (a 6.8% error rate)&quot; P&lt;0.001<p /> <a href="http://content.nejm.org/cgi/content/short/362/18/1698">http://content.nejm.org/cgi/content/short/362/18/1698</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/nejm-effect-of-bar-code-technology-on-the-saf-0">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7265295957782990074?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-21506668061360847882010-05-06T17:59:00.001-07:002010-05-06T17:59:40.381-07:00<div class='posterous_autopost'><a href="http://www3.interscience.wiley.com/journal/123417345/abstract?CRETRY=1&amp;SRETRY=0">http://www3.interscience.wiley.com/journal/123417345/abstract?CRETRY=1&amp;SRETRY=0</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/analysis-of-a-polymorphic-microrna-target-sit">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2150666806136084788?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-8075281123782763182010-05-06T17:19:00.001-07:002010-05-06T17:19:24.840-07:00<div class='posterous_autopost'><div>&quot;a draft sequence ofthe Neandertal genome composed of more than 4 billion nucleotidesfrom three individuals. Comparisons of the Neandertal genometo the genomes of five present-day humans from different partsof the world&quot;</div><p /><a href="http://www.sciencemag.org/cgi/content/full/328/5979/710">http://www.sciencemag.org/cgi/content/full/328/5979/710</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/science-a-draft-sequence-of-the-neandertal-ge">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-807528112378276318?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-38798035159845504062010-05-06T09:57:00.001-07:002010-05-06T09:57:01.399-07:00<div class='posterous_autopost'><div>n=23 cases </div><div>77 controls</div><div><span style="font-family: Lucida Grande, Lucida Sans Unicode, Tahoma, Verdana, Arial, Helvetica, sans-serif; font-size: 13px; line-height: 19px;">&quot;immune system functions are significantly overrepresented among the annotations associated with genes uniquely unmethylated among those with PTSD.&quot;</span></div> <p /><div>Could this be a result of HPA axis dysregulation?</div><p /><a href="http://www.pnas.org/content/early/2010/04/19/0910794107">http://www.pnas.org/content/early/2010/04/19/0910794107</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/pnas-epigenetic-and-immune-function-profiles">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3879803515984550406?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-77021868902557503012010-05-06T09:06:00.001-07:002010-05-06T09:06:02.064-07:00<div class='posterous_autopost'><div>&quot;impending collapse of the genome informatics ecosystem&quot;</div><p /><a href="http://genomebiology.com/2010/11/5/207">http://genomebiology.com/2010/11/5/207</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/the-case-for-cloud-computing-in-genome-inform">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7702186890255750301?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-32631753325828892232010-05-02T22:04:00.001-07:002010-05-02T22:04:39.882-07:00<div class='posterous_autopost'><div>128 founders (78 females and 50 males) accounted for over 95% of the mean relative founder contribution among living Old Order Amish descendants, according to analyses with PedHunter 2.0.</div><p /><div><a href="http://www.biomedcentral.com/1471-2350/11/68/abstract">http://www.biomedcentral.com/1471-2350/11/68/abstract</a><br /> </div> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/bmc-medical-genetics-characterizing-the-found">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3263175332582889223?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-13465243298609490492010-05-02T21:05:00.001-07:002010-05-02T21:05:33.998-07:00<div class='posterous_autopost'>"The objectives of new media have tended, fatally, to be set in terms of the parameters and frames of the older media." <p /> -Marshall McLuhan <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/mcluhan-on-the-objectives-of-new-media">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1346524329860949049?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-61584905107699848682010-05-02T20:00:00.001-07:002010-05-02T20:00:49.733-07:00<div class='posterous_autopost'>Machines don't make things perfect. Some of the known issues with <br />computers in health care are discussed, including electronic ordering. <p /> <a href="http://www.huffingtonpost.com/2010/04/20/electronic-medical-record_n_545441.html">http://www.huffingtonpost.com/2010/04/20/electronic-medical-record_n_545441.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/huffingtonpost-electronic-medical-record-shif">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6158490510769984868?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-63761639821179074032010-04-30T06:41:00.001-07:002010-04-30T06:41:34.342-07:00<div class='posterous_autopost'><p><a href="http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960452-7/fulltext">http://www.thelancet.com/journals/lancet/article/PIIS0140-6736%2810%2960452-7/fulltext</a></p> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/lancet-case-report-clinical-genome-via-thelan">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6376163982117907403?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-49080615643329530502010-04-29T20:47:00.001-07:002010-04-29T20:47:17.191-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/s9IfHafaD1h1NH925JTGNFvkr1G7Rk8F9BB6f8BVjgm28Fq9qhFFb72bg0ov/IMAG0135_edit0.jpg'><img src="http://posterous.com/getfile/files.posterous.com/nocx/azVkCPxbaccENVXhiDwboOCA3poWhWN1bBxvfAy9rhSPZfYxqRC3LMM3lmdV/IMAG0135_edit0.jpg.scaled.500.jpg" width="500" height="315"/></a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/facade-photo">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4908061564332953050?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-55464003962852837852010-04-28T21:25:00.001-07:002010-04-28T21:25:07.890-07:00<div class='posterous_autopost'><a href='http://posterous.com/getfile/files.posterous.com/nocx/Ma4kVVaeVYY9nD5bFs5EMANKcENoNvPugxDJbXTNq4YTakdMLZxwRuy7OqUO/IMAG0130_edit0.jpg'><img src="http://posterous.com/getfile/files.posterous.com/nocx/aHkXmPKVWAL38KHxm79Cpn5kf0Km70d6yhtMZwK1oVXxrecY5cWBMQSUEMro/IMAG0130_edit0.jpg.scaled.500.jpg" width="500" height="227"/></a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/waterloos-perimeter-institute-pic">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-5546400396285283785?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-36445044708232650762010-04-28T21:23:00.001-07:002010-04-28T21:23:38.548-07:00<div class='posterous_autopost'>Yu et al. on <a href="http://www.biomedcentral.com/1472-6947/10/16">machine learning and diabetes phenotypes</a>. <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/application-of-support-vector-machine-modelin">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3644504470823265076?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-12793460867047640922010-04-27T19:51:00.001-07:002010-04-27T19:51:25.694-07:00<div class='posterous_autopost'><object height="417" width="500"><param name="movie" value="http://www.youtube.com/v/t4FKO85irvw&hl=en&fs=1" /></param><param name="wmode" value="window" /><param name="allowFullScreen" value="true" /></param><param name="allowscriptaccess" value="always" /></param><embed src="http://www.youtube.com/v/t4FKO85irvw&hl=en&fs=1" allowfullscreen="true" type="application/x-shockwave-flash" allowscriptaccess="always" wmode="window" height="417" width="500"></embed></object> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/how-to-turn-your-pubmed-search-into-an-rss-fe">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1279346086704764092?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-32106113992543647672010-04-27T09:32:00.001-07:002010-04-27T09:32:50.055-07:00<div class='posterous_autopost'>A study with peripheral lymphocyte DNA.<br /><a href="http://www.ncbi.nlm.nih.gov/pubmed/18536702">http://www.ncbi.nlm.nih.gov/pubmed/18536702</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/functional-analysis-of-a-potassium-chloride-c">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-3210611399254364767?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-17876044438639141512010-04-25T20:39:00.001-07:002010-04-25T20:39:11.301-07:00<div class='posterous_autopost'>ViaVoice for GNU/Linux was pulled by IBM.<br />Current/future possiblities might include <a href="http://blog.eracc.com/2010/02/28/gnulinux-current-state-of-voice-dictation-and-recognition/">simon and CMU Sphinx</a>. <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/the-state-of-speech-recognition-in-gnulinux">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1787604443863914151?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-68596680683298179072010-04-25T12:46:00.001-07:002010-04-25T12:46:53.983-07:00<div class='posterous_autopost'>&quot;If someone takes something that belongs to you, and puts a lock on it that you don&#39;t have a key for, that lock isn&#39;t in your best interests.&quot;<br />&quot;Anytime someone puts a lock on something you own, against your wishes, and doesn&#39;t give you the key, they&#39;re not doing it for your benefit.&quot;<br />-Cory Doctorow<p />In his recent <a href="http://www.publishersweekly.com/article/456751-Can_You_Survive_a_Benevolent_Dictatorship_.php">Publisher&#39;s Weekly article</a>, Cory reviews why &quot;Already, Apple&#39;s App Store has displayed the warning signs of a less-than-benevolent dictator.&quot;<p /> ______________________________________________________________________________________________________________________<p /><a href="http://www.eff.org/deeplinks/2009/04/doctorows-law">http://www.eff.org/deeplinks/2009/04/doctorows-law</a><p /> <a href="http://www.theimaginationage.net/2009/02/doctorows-law.html">http://www.theimaginationage.net/2009/02/doctorows-law.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/doctorows-law-applied-to-drm-a-benevolent-dic">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6859668068329817907?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-60330531053554951332010-04-24T10:55:00.001-07:002010-04-24T10:55:37.088-07:00<div class='posterous_autopost'><a href="http://www.socialnetworkingtodayblog.com/?tag=best-time-to-tweet">http://www.socialnetworkingtodayblog.com/?tag=best-time-to-tweet</a><p /><a href="http://thesocialmediaguide.com.au/2010/04/04/when-is-the-best-time-to-tweet/">http://thesocialmediaguide.com.au/2010/04/04/when-is-the-best-time-to-tweet/</a><p /> <a href="http://www.garymccaffrey.com/blog/2009/03/19/when-is-the-best-time-to-tweet-for-maximum-twitter-traffic-and-exposure/">http://www.garymccaffrey.com/blog/2009/03/19/when-is-the-best-time-to-tweet-for-maximum-twitter-traffic-and-exposure/</a><p /> <a href="http://www.personalbrandingblog.com/30-minute-brand-building-for-twitter/">http://www.personalbrandingblog.com/30-minute-brand-building-for-twitter/</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/peaking-on-twitter-twitter-peak-times-when-do">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-6033053105355495133?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-40131971335982154722010-04-23T07:07:00.001-07:002010-04-23T07:07:39.731-07:00<div class='posterous_autopost'>Knowl Inf Sys (2008)<p /><a href="http://ow.ly/1C6Ay">http://ow.ly/1C6Ay</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/rt-moorejh-nice-wwwilson-top-10-algorithms-in">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4013197133598215472?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-20046687538865393832010-04-21T08:49:00.001-07:002010-04-21T08:49:42.300-07:00<div class='posterous_autopost'><span class="status-body"><span class="status-content"><span class="entry-content"><a href="http://bit.ly/bVkXiX" class="tweet-url web" rel="nofollow" target="_blank">http://bit.ly/bVkXiX</a> </span></span></span> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/rt-biomedcentral-new-software-called-mochivie">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-2004668753886539383?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-72837877345922744802010-04-21T08:45:00.001-07:002010-04-21T08:45:53.438-07:00<div class='posterous_autopost'>Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain<p /><a href="http://www.fasebj.org/cgi/content/abstract/fj.10-154484v1">http://www.fasebj.org/cgi/content/abstract/fj.10-154484v1</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/faseb-journal-lymphoblastoid-cell-lines-sugge">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-7283787734592274480?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-18072357697332479602010-04-21T07:54:00.001-07:002010-04-21T07:54:30.448-07:00<div class='posterous_autopost'>&quot;supports the use of the lymphoblasts as a surrogate to study miRNA expression in ASD&quot;<p /><a href="http://bit.ly/bJs6li" class="tweet-url web" rel="nofollow" target="_blank">http://bit.ly/bJs6li</a><p /><a href="http://genomemedicine.com/content/2/4/23/abstract">http://genomemedicine.com/content/2/4/23/abstract</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/altered-microrna-expression-in-autism-via-pub">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1807235769733247960?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-47193730740841949772010-04-17T19:53:00.001-07:002010-04-17T19:53:33.034-07:00<div class='posterous_autopost'><a href="http://genome.cshlp.org/content/19/1/92.full.pdf%2Bhtml">http://genome.cshlp.org/content/19/1/92.full.pdf%2Bhtml</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/most-mammalian-mrnas-are-conserved-targets-of">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4719373074084194977?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-17545313269583929442010-04-16T11:48:00.001-07:002010-04-16T11:48:19.290-07:00<div class='posterous_autopost'><a href="http://www.voltaicsystems.com/bag_converter.shtml">http://www.voltaicsystems.com/bag_converter.shtml</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/anybody-tried-this-one-voltaic-systems-solar">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-1754531326958392944?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0tag:blogger.com,1999:blog-4303195686193514194.post-45171308543051814382010-04-16T11:27:00.001-07:002010-04-16T11:27:32.348-07:00<div class='posterous_autopost'><div>&quot;FGF2-treated rats showed less renewal of fear when tested in the original training context than did vehicle-treated rats. This pattern occurred even when vehicle rats were given double the amount of extinction training, and when FGF2-treated rats were given equivalent exposure to the extinction context. These results show that FGF2 facilitates long-term extinction and attenuates relapse, and thus highlight its potential as a novel pharmacological adjunct to exposure therapy.&quot;</div><p /><a href="http://www.nature.com/npp/journal/v35/n6/abs/npp20103a.html">http://www.nature.com/npp/journal/v35/n6/abs/npp20103a.html</a> <p style="font-size: 10px;"> <a href="http://posterous.com">Posted via email</a> from <a href="http://nocx.posterous.com/fibroblast-growth-factor-2-enhances-extinctio">the nocx files</a> </p> </div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/4303195686193514194-4517130854305181438?l=nocx.blogspot.com' alt='' /></div>nocxhttp://www.blogger.com/profile/07228111941253043639noreply@blogger.com0